Methamphetamine‐induced dopaminergic neurotoxicity: role of peroxynitrite and neuroprotective role of antioxidants and peroxynitrite decomposition catalysts

…, J EL‐YAZAL, GD Newport, Y Itzhak… - Annals of the New …, 2001 - Wiley Online Library
Oxidative stress, reactive oxygen (ROS), and nitrogen (RNS) species have been known to
be involved in a multitude of neurodegenerative disorders such as Parkinson's disease (PD), …

The peripheral benzodiazepine receptor and neurosteroids in hepatic encephalopathy

MD Norenberg, Y Itzhak, AS Bender - Advances in cirrhosis …, 1997 - Springer
Hepatic encephalopathy (HE) represents one of the most common events in terminal liver
failure. Acute HE (fulminant hepatic failure, FHF) presents with the abrupt onset of delirium, …

[HTML][HTML] Cocaine-induced conditioned place preference in mice: induction, extinction and reinstatement by related psychostimulants

Y Itzhak, JL Martin - Neuropsychopharmacology, 2002 - nature.com
Reinstatement of drug-seeking behavior in animals is relevant to drug relapse in humans. In
the present study, we employed the conditioned place preference (CPP) paradigm to …

Role of nitrergic system in behavioral and neurotoxic effects of amphetamine analogs

Y Itzhak, SF Ali - Pharmacology & therapeutics, 2006 - Elsevier
Several amphetamine analogs are potent psychostimulants and major drugs of abuse. In
animal models, the psychomotor and reinforcing effects of amphetamine, methamphetamine (…

[HTML][HTML] Effects of cocaine, nicotine, dizocipline and alcohol on mice locomotor activity: cocaine–alcohol cross-sensitization involves upregulation of striatal dopamine …

Y Itzhak, JL Martin - Brain research, 1999 - Elsevier
We investigated if repeated administration of cocaine, nicotine, dizocipline (MK-801) and
alcohol yields behavioral cross-sensitization between these agents. Swiss Webster mice …

The neuronal nitric oxide synthase inhibitor, 7‐nitroindazole, protects against methamphetamine‐induced neurotoxicity in vivo

Y Itzhak, SF Ali - Journal of neurochemistry, 1996 - Wiley Online Library
The present study was undertaken to investigate whether the relatively selective neuronal
nitric oxide synthase (NOS) inhibitor, 7‐nitroindazole (7‐NI), protects against …

Impairments in fear conditioning in mice lacking the nNOS gene

…, MA Balda, KL Anderson, Y Itzhak - Learning & …, 2009 - learnmem.cshlp.org
The fear conditioning paradigm is used to investigate the roles of various genes, neurotransmitters,
and substrates in the formation of fear learning related to contextual and auditory …

Modulation of cocaine-and methamphetamine-induced behavioral sensitization by inhibition of brain nitric oxide synthase

Y Itzhak - Journal of Pharmacology and Experimental …, 1997 - ASPET
Evidence suggests the existence of multiple interactions between dopamine, glutamate and
nitric oxide (NO) in brain structures associated with psychomotor stimulation. The present …

Peroxynitrite plays a role in methamphetamine‐induced dopaminergic neurotoxicity: evidence from mice lacking neuronal nitric oxide synthase gene or …

SZ Imam, GD Newport, Y Itzhak, JL Cadet… - Journal of …, 2001 - Wiley Online Library
The use of methamphetamine (METH) leads to neurotoxic effects in mammals. These
neurotoxic effects appear to be related to the production of free radicals. To assess the role of …

Resistance of neuronal nitric oxide synthase-deficient mice to methamphetamine-induced dopaminergic neurotoxicity

Y Itzhak, C Gandia, PL Huang, SF Ali - Journal of Pharmacology and …, 1998 - ASPET
Methamphetamine (METH) is a powerful psychostimulant that produces dopaminergic
neurotoxicity manifested by a decrease in the levels of dopamine, tyrosine hydroxylase activity …