In neonatal cardiomyocytes, activation of the G q -coupled α 1 -adrenergic receptor (α 1 AR)
induces hypertrophy by activating mitogen-activated protein kinases, including c-Jun NH 2 -…

To evaluate the influence of chronic alcoholism on clinical features of chronic pancreatitis in
Japan, pain evolution, pancreatic insufficiency, and long-term prognosis were studied by …

We have developed a novel and potent chemical series of 5,5-diphenylpentadienamides for
targeting TRPV1 in vitro and in vivo. In this investigation, we examined a variety of …

We examined the subtype-selective binding site of the β-adrenergic receptors (βARs). The β
1 /β 2 -chimeric receptors showed the importance of the second and seventh …

Cases of pancreas divisum (PD) were reviewed in our patients and 19 Japanese and 14
English series during the past 10 yr to see any significant association of PD with certain …

Transmembrane domains (TMDs) I, II, and VII of the β 2 -adrenergic receptor (β 2 AR) were
replaced, individually or in combination, with the corresponding regions of the β 1 AR, and …

Prostate-specific membrane antigen (PSMA) is an attractive target for treatment of prostate
cancer. Using the PSMA-recognizing mouse monoclonal antibody 2C9 obtained in our …

TROP-2 is a type Ⅰ transmembrane glycoprotein that is highly expressed in various
epithelial cancer cells, and its increased expression correlates with poor prognosis. Although …

A46-year-old female patient whowas diagnosed with systemic sclerosis (SSc) developed
rapidly progressive renal failure without elevation of blood pressure or plasma renin concentra-…

(−)-1-(3,4-Dimethoxyphenetylamino)-3-(3,4-dihydroxy)-2-propanol [(−)-RO363] is a highly
selective β 1 -adrenergic receptor (β 1 AR) agonist. To study the binding site of β 1 -selective …