User profiles for Yi-Zhun Zhu

Yi Zhun Zhu, MD, Ph.D.

Chair Professor of Pharmacology, Dean of Pharmacy, Macau Uni. of Sci. & Tech.
Verified email at must.edu.mo
Cited by 18001

Hydrogen sulfide is a novel mediator of lipopolysaccharide‐induced inflammation in the mouse

L Li, M Bhatia, YZ Zhu, YC Zhu, RD Ramnath… - The FASEB …, 2005 - Wiley Online Library
Hydrogen sulfide (H 2 S) is synthesized in the body from l‐cysteine by several enzymes
including cystathionine‐γ‐lyase (CSE). To date, there is little information about the potential role …

Hydrogen sulphide: a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain?

M Whiteman, NS Cheung, YZ Zhu, SH Chu… - Biochemical and …, 2005 - Elsevier
Hydrogen sulphide (H 2 S) is a cytotoxic gas that has recently been proposed as a novel
neuromodulator. Endogenous levels of H 2 S in the brain range between 50 and 160μM, and …

Bioactive S-alk (en) yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents

P Rose, M Whiteman, PK Moore, YZ Zhu - Natural product reports, 2005 - pubs.rsc.org
Yi Zhun Zhu Yi Zhun Zhu Yi Zhun Zhu is a senior research fellow at the Department of
Pharmacology, National University of Singapore and Professor of Pharmacology at Fudan …

Oxidative stress: apoptosis in neuronal injury

…, R De Silva, BK H Tan, Y Zhun Zhu - Current Alzheimer …, 2006 - ingentaconnect.com
Apoptosis has been well documented to play a significant role in cell loss during neurodengerative
disorders, such as stroke, Parkinson disease, and Alzheimer's disease. In addition, …

Hydrogen sulfide and its possible roles in myocardial ischemia in experimental rats

YZ Zhu, ZJ Wang, P Ho, YY Loke… - Journal of Applied …, 2007 - journals.physiology.org
The role of hydrogen sulfide (H 2 S) in myocardial infarction (MI) has not been previously
studied. We therefore investigated the effect of H 2 S in a rat model of MI in vivo. Animals were …

[HTML][HTML] Signaling pathways in rheumatoid arthritis: implications for targeted therapy

…, M Zhu, M Li, J Cai, P Rose, J Mao, YZ Zhu - Signal transduction and …, 2023 - nature.com
Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease progression
leads to joint deformity and associated loss of function, which significantly impacts the …

Salvia miltiorrhiza and ischemic diseases.

XY Ji, BK Tan, YZ Zhu - Acta Pharmacologica Sinica, 2000 - europepmc.org
The demonstration of beneficial effects of salvia miltiorrhiza (DanShen) on ischemic diseases
has revolutionized the management of angina pectoris, myocardial infarction (MI) or stroke …

Metabolism and transport of oxazaphosphorines and the clinical implications

…, S Chuen Li, S Zhou, W Duan, YZ Zhu - Drug metabolism …, 2005 - Taylor & Francis
The oxazaphosphorines including cyclophosphamide (CPA), ifosfamide (IFO), and trofosfamide
represent an important group of therapeutic agents due to their substantial antitumor …

[HTML][HTML] Hydrogen sulfide protects HUVECs against hydrogen peroxide induced mitochondrial dysfunction and oxidative stress

…, SH Kho, S Rinkiko, X Sheng, HM Shen, YZ Zhu - PloS one, 2013 - journals.plos.org
Background Hydrogen sulfide (H 2 S) has been shown to have cytoprotective effects in models
of hypertension, ischemia/reperfusion and Alzheimer's disease. However, little is known …

VEGFR2 Functions As an H2S-Targeting Receptor Protein Kinase with Its Novel Cys1045–Cys1024 Disulfide Bond Serving As a Specific Molecular Switch for …

…, Y Chen, LJ Zhang, YZ Zhu, YC Zhu - Antioxidants & redox …, 2013 - liebertpub.com
Aims: The potential receptor for hydrogen sulfide (H 2 S) remains unknown. Results: H 2 S
could directly activate vascular endothelial growth factor receptor 2 (VEGFR2) and that a …