G9a is a mammalian histone methyltransferase that contributes to the epigenetic silencing of
tumor suppressor genes. Emerging evidence suggests that G9a is required to maintain the …

The up-regulation of fucosyltransferase 8 (FUT8), the only enzyme catalyzing α1,6-fucosylation
in mammals, has been observed in several malignant cancers including liver, ovarian, …

Despite a general repression of translation under hypoxia, cells selectively upregulate a set
of hypoxia-inducible genes. Results from deep sequencing revealed that Let-7 and miR-103/…

Background Ovarian cancer (OCa) peritoneal metastasis is the leading cause of cancer–related
deaths in women with limited therapeutic options available for treating it and poor …

Sulfur mustard (SM) is a chemical weapon that targets the skin, eyes, and lung. It was first
employed during World War I and it remains a significant military and civilian threat. As a …

The interplay between tumor microenvironment and cancer that causes chemoresistance
remains unclear. By analyzing public available microarray datasets, we identified that periostin …

Biomarkers predicting metastatic capacity might assist the development of better therapeutic
strategies for aggressive cancers such as lung cancer. In this study, we show that adenylate …

Background Adenylate kinase 4 (AK4) has been identified as a biomarker of metastasis in
lung cancer. However, the impacts of AK4 on metabolic genes and its translational value for …

Acetaminophen (APAP) is metabolized in the liver to N-acetyl-p-benzoquinone imine (NAPQI),
an electrophilic metabolite known to bind liver proteins resulting in hepatotoxicity. …

Rationale: Metabolic alterations contribute to cancer development and progression. However,
the molecular mechanisms relating metabolism to cancer metastasis remain largely …