LCZ696, an angiotensin receptor–neprilysin inhibitor, improves cardiac function with the attenuation of fibrosis in heart failure with reduced ejection fraction in …

Y Suematsu, S Miura, M Goto, Y Matsuo… - European journal of …, 2016 - Wiley Online Library
Aims Angiotensin receptor–neprilysin inhibitors ( ARNis ) acts an ARB and neprilysin
inhibitor. Diabetes mellitus significantly increases the risk of cardiovascular disease and heart …

LCZ696 (sacubitril/valsartan), an angiotensin-receptor neprilysin inhibitor, attenuates cardiac hypertrophy, fibrosis, and vasculopathy in a rat model of chronic kidney …

Y Suematsu, W Jing, A Nunes, ML Kashyap… - Journal of cardiac …, 2018 - Elsevier
Background Chronic kidney disease (CKD) is associated with cardiac hypertrophy, fibrosis,
and increased risk of cardiovascular mortality. LCZ696 (sacubitril/valsartan) is a promising …

[HTML][HTML] LCZ696 (Sacubitril/valsartan) ameliorates oxidative stress, inflammation, fibrosis and improves renal function beyond angiotensin receptor blockade in CKD

W Jing, ND Vaziri, A Nunes, Y Suematsu… - American journal of …, 2017 - ncbi.nlm.nih.gov
Progressive deterioration of kidney function in chronic kidney disease (CKD) is mediated by
hypertension, oxidative stress, inflammation, and fibrosis. Renin-angiotensin blockade is …

Impact of Cigarette Smoking Cessation on High-Density Lipoprotein Functionality–VN-SEESAW-HDL–

K Takata, S Imaizumi, E Kawachi, Y Suematsu… - Circulation …, 2014 - jstage.jst.go.jp
Background: Smoking cessation reduces the risk of cardiovascular disease (CVD) and
improves clinical outcomes in public health. We studied the effect of smoking cessation on high-…

The phosphate binder ferric citrate alters the gut microbiome in rats with chronic kidney disease

…, W England, M Khazaeli, Y Suematsu… - … of Pharmacology and …, 2018 - ASPET
In chronic kidney disease (CKD), the gut microbiome is altered and bacterial-derived uremic
toxins promote systemic inflammation and cardiovascular disease. Ferric citrate complex is …

Association between smoking habits and severity of coronary stenosis as assessed by coronary computed tomography angiography

M Yano, S Miura, Y Shiga, Y Miyase, Y Suematsu… - Heart and vessels, 2016 - Springer
Smoking promotes arteriosclerosis and is one of the most important coronary risk factors.
However, few studies have investigated the association between smoking habits and the …

[PDF][PDF] Optimal kissing balloon inflation after single-stent deployment in a coronary bifurcation model

…, T Yamamoto, T Yagi, Y Hikichi, Y Suematsu… - …, 2014 - researchgate.net
Aims: To define the optimal kissing balloon inflation (KBI) after single-stent deployment in a
coronary bifurcation model. Methods and results: We deployed stents in main vessels (MV) …

Rivaroxaban, a factor Xa inhibitor, induces the secondary prevention of cardiovascular events after myocardial ischemia reperfusion injury in mice

M Goto, S Miura, Y Suematsu, Y Idemoto… - International journal of …, 2016 - Elsevier
Objectives Rivaroxaban has been shown to reduce overall death from cardiovascular causes
in patients with recent acute coronary syndrome. Therefore, we evaluated the secondary …

[HTML][HTML] Impact of cigarette smoking cessation on plasma α-klotho levels

Y Kamizono, Y Shiga, Y Suematsu, S Imaizumi… - Medicine, 2018 - journals.lww.com
Smoking cessation reduces the risk of cardiovascular disease and improves clinical outcomes.
We studied the effect of smoking cessation on plasma levels of α-klotho, which is an …

[HTML][HTML] Reactive hyperemia index associated with atherosclerotic cardiovascular disease under treatment for lifestyle diseases

K Motozato, Y Suematsu, K Norimatsu… - Journal of clinical …, 2020 - ncbi.nlm.nih.gov
Background Endothelial dysfunction is an early phase of atherosclerosis and causes
atherosclerotic cardiovascular disease (ASCVD), but the cutoff reactive hyperemia index (RHI) for …