Microbial functions in the host physiology are a result of the microbiota-host co-evolution. We
show that cold exposure leads to marked shift of the microbiota composition, referred to as …

The binding of RGD peptides to integrins offers an excellent system to study the multivalent
mediated changes in affinity that arise when peptides, displayed on the surface of a …

Brown adipose tissue (BAT) promotes a lean and healthy phenotype and improves insulin
sensitivity 1 . In response to cold or exercise, brown fat cells also emerge in the white adipose …

Nanoparticles 10 to 100 nm in size can deliver large payloads to molecular targets, but undergo
slow diffusion and/or slow transport through delivery barriers. To examine the feasibility …

Objectives The purpose of this study was to assess the diagnostic image quality of ultra-low-dose
chest computed tomography (ULD-CT) obtained with a radiation dose comparable to …

Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) combined with magnetic resonance
imaging (MRI) are under clinical evaluation to enhance detection of neurodegenerative …

Reactive oxygen species, ROS, are regulators of endothelial cell migration, proliferation
and survival, events critically involved in angiogenesis. Different isoforms of ROS-generating …

Designing molecules that bind to targets that become upregulated or overexpressed as normal
cells become cancerous is an important strategy for both therapeutic and diagnostic drug …

Methods that allow robust imaging of specific molecular targets and biological processes in
vivo should have widespread applications in biology and clinical medicine. Here we use a …

Purpose: To prospectively determine the feasibility of imaging vascular volume fraction (VVF)
and its therapeutic inhibition in mouse models of cancer with three-dimensional …