The 5‐HT1A and 5‐HT1B receptors of serotonin play important roles as auto‐ and heteroreceptors
controlling the release of serotonin itself and of other neurotransmitters/modulators in …

Substantial evidence indicates an association between clinical depression and altered
immune function. Systemic administration of bacterial lipopolysaccharide (LPS) is commonly …

The cloning of novel G protein-coupled receptors and the search for their natural ligands, a
process called reverse pharmacology, is an excellent opportunity to discover novel …

We examined the pharmacological profile of (3,4-dihydro-2H-pyrano[2,3]b quinolin-7-yl) (cis-4-methoxycyclohexyl)
methanone (JNJ16259685). At recombinant rat and human …

The anatomical localization of 5‐HT 4 receptor mRNA and 5‐HT 4 receptor protein was
examined in sections of post‐mortem human brain by in situ hybridization histochemistry and …

Of all partners involved in G‐protein coupled receptor (GPCR) signalling, the regulator of G‐protein
signalling (RGS) proteins are the only ones showing fast gene expression changes …

Diblock PEG-p(CL-co-TMC) [methoxypoly(ethylene glycol)-poly(caprolactone/trimethylene
carbonate)] copolymers form micelles spontaneously and significantly increase the solubility …

The P2X7 receptor (P2X7R) orchestrates neuroinflammation, and this is the basis for an
increased interest in the development of antagonists inhibiting P2X7R function in the brain. This …

1-[8-(2,4-dichlorophenyl)-2-methylquinolin-4-yl]-1,2,3,6-tetrahydropyridine-4-carboxamide
benzenesulfonate (R278995/CRA0450) is a newly synthesized corticotropin-releasing factor …

Background Kinetic modeling of physiological function using imaging techniques requires
the accurate measurement of the time-activity curve of the tracer in plasma, known as the …