Vaccination with an alkaline extract of Histoplasma capsulatum packaged in glucan particles confers protective immunity in mice

GS Deepe Jr, WR Buesing, GR Ostroff, A Abraham… - Vaccine, 2018 - Elsevier
Infection with the dimorphic fungus, Histoplasma capsulatum, occurs world-wide, but North
and South America are regions of high endemicity. Interventions to mitigate exposure and …

Long-term behavioral consequences of prenatal MDMA exposure

…, J Heiman, JB Chambers, SC Benoit, WR Buesing… - Physiology & …, 2009 - Elsevier
The current study sought to determine whether prenatal 3,4-methylenedioxy-N-methamphetamine
(MDMA) exposure from E14–20 in the rat resulted in behavioral sequelae in adult …

Deciphering the pathways of death of Histoplasma capsulatum-infected macrophages: implications for the immunopathogenesis of early infection

GS Deepe, WR Buesing - The Journal of Immunology, 2012 - journals.aai.org
Apoptosis of leukocytes is known to strongly influence the immunopathogenesis of infection.
In this study, we dissected the death pathways of murine macrophages (MΦs) infected with …

A chimeric human/murine anticocaine monoclonal antibody inhibits the distribution of cocaine to the brain in mice

AB Norman, MR Tabet, MK Norman, WR Buesing… - … of Pharmacology and …, 2007 - ASPET
The predominantly human sequence, high-affinity anticocaine monoclonal antibody (mAb)
2E2 was cleared slowly from mouse blood by a first-order process with an elimination t 1/2 of …

The effect of a chimeric human/murine anti-cocaine monoclonal antibody on cocaine self-administration in rats

AB Norman, MK Norman, WR Buesing, MR Tabet… - … of Pharmacology and …, 2009 - ASPET
The predominantly human sequence anti-cocaine monoclonal antibody (mAb), 2E2, has high
affinity and specificity for cocaine and antagonizes cocaine distribution to the brain in mice. …

[HTML][HTML] A metabolic inhibitor arms macrophages to kill intracellular fungal pathogens by manipulating zinc homeostasis

DCP Rossi, JAL Figueroa, WR Buesing… - The Journal of …, 2021 - Am Soc Clin Investig
Macrophages deploy numerous strategies to combat invasion by microbes. One tactic is to
restrict acquisition of diverse nutrients, including trace metals, a process termed nutritional …

Utilization of a Histoplasma capsulatum zinc reporter reveals the complexities of fungal sensing of metal deprivation

LT Blancett, HM Evans, K Candor, WR Buesing… - Msphere, 2024 - Am Soc Microbiol
Histoplasma capsulatum is a dimorphic fungal pathogen acquired via inhalation of soil-resident
spores. Upon exposure to mammalian body temperatures, these fungal elements …

The self-administration of WIN 35,428 and cocaine: comparisons of satiety threshold and elimination half-life in rats

AB Norman, WR Buesing, MK Norman… - European journal of …, 2004 - Elsevier
Rats that self-administered cocaine at unit doses between 0.75 and 12 μmol/kg with mean
inter-injection intervals between approximately 2 and 18 min also reliably self-administered …

1195. Influence of Histoplasma capsulatum Infection on Endothelin-1 mRNA Gene Expression in Bone Marrow Derived Macrophages

E Ajayi, GS Deepe, WR Buesing - Open Forum Infectious Diseases, 2020 - ncbi.nlm.nih.gov
Background Endothelin-1 (ET-1) is increasingly recognized as an immune modulator; it exerts
a pro-inflammatory effect by increasing the release of cytokines like interferon gamma. ET-…

A human anti‐cocaine monoclonal antibody antagonizes the cocaine‐induced reinstatement of self‐administration in rats

AB Norman, MK Norman, WR Buesing, MR Tabet… - 2008 - Wiley Online Library
Immunotherapy may represent a viable alternative to pharmacotherapy for cocaine abuse.
The predominantly human sequence anti‐cocaine monoclonal antibody, 2E2, has high …