Estrogens have long been implicated in influencing cognitive processes, yet the molecular
mechanisms underlying these effects and the roles of the estrogen receptors alpha (ERα) and …

Astrocytes are the most populous glial subtype and are critical for brain function. Despite this,
historically there have been few studies into the role that they may have in …

6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide
hydrochloride (GSK189254) is a novel histamine H 3 receptor antagonist with high …

The recent cloning of two GABA B receptor subunits, GABA B1 and GABA B2 , has raised
the possibility that differences in GABA B receptor subunit composition may give rise to …

Recent studies show that intracellular cholesterol levels can modulate the processing of
amyloid precursor protein to Aβ peptide. Moreover, cholesterol-rich apoE-containing …

GABA B receptors are unique among G-protein-coupled receptors (GPCRs) in their requirement
for heterodimerization between two homologous subunits, GABA B1 and GABA B2 , for …

SB-399885 (N-[3,5-dichloro-2-(methoxy)phenyl]-4-(methoxy)-3-(1-piperazinyl)benzenesulfonamide)
has high affinity for human recombinant and native 5-HT 6 receptors, with pK i …

With the advent of the genetic era in Parkinson’s disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects >…

There is increasing evidence for a role of 5-hydroxytrypta-mine-6 (5-HT 6 ) receptors in cognitive
function. In the rat and human brain, 5-HT 6 receptors are widely expressed and highly …

Lysosomal dysfunction plays a central role in the pathogenesis of several neurodegenerative
disorders, including Parkinson's disease (PD). Several genes linked to genetic forms of PD…