A review on the assembly of multi-substituted pyridines via Co-catalyzed [2+ 2+ 2] cycloaddition with nitriles
K Cen, M Usman, W Shen, M Liu, R Yang… - Organic & Biomolecular …, 2022 - pubs.rsc.org
In recent years, many methods for the facile synthesis of pyridines and their derivatives have
been developed. The [2 + 2 + 2] cycloaddition reaction of alkynes and nitriles catalyzed by …
been developed. The [2 + 2 + 2] cycloaddition reaction of alkynes and nitriles catalyzed by …
Why does fever trigger febrile seizures? GABAA receptor γ2 subunit mutations associated with idiopathic generalized epilepsies have temperature-dependent …
JQ Kang, W Shen, RL Macdonald - Journal of Neuroscience, 2006 - Soc Neuroscience
With a worldwide incidence as high as 6.7% of children, febrile seizures are one of the most
common reasons for seeking pediatric care, but the mechanisms underlying generation of …
common reasons for seeking pediatric care, but the mechanisms underlying generation of …
Azithromycin causes a novel proarrhythmic syndrome
Z Yang, JK Prinsen, KR Bersell, W Shen… - Circulation …, 2017 - Am Heart Assoc
Background— The widely used macrolide antibiotic azithromycin increases risk of cardiovascular
and sudden cardiac death, although the underlying mechanisms are unclear. Case …
and sudden cardiac death, although the underlying mechanisms are unclear. Case …
Rapid stimulation causes electrical remodeling in cultured atrial myocytes
Z Yang, W Shen, JN Rottman, JP Wikswo… - Journal of molecular and …, 2005 - Elsevier
Objective. – Rapid stimulation causes electrical remodeling in the intact atrium, with shortening
of action potential duration (APD), down-regulation of L-type Ca 2+ currents (I Ca,L ), and …
of action potential duration (APD), down-regulation of L-type Ca 2+ currents (I Ca,L ), and …
The human epilepsy mutation GABRG2(Q390X) causes chronic subunit accumulation and neurodegeneration
JQ Kang, W Shen, C Zhou, D Xu, RL Macdonald - Nature neuroscience, 2015 - nature.com
Genetic epilepsy and neurodegenerative diseases are two common neurological disorders
that are conventionally viewed as being unrelated. A subset of patients with severe genetic …
that are conventionally viewed as being unrelated. A subset of patients with severe genetic …
De novo GABRG2 mutations associated with epileptic encephalopathies
D Shen, CC Hernandez, W Shen, N Hu, A Poduri… - Brain, 2017 - academic.oup.com
Epileptic encephalopathies are a devastating group of severe childhood onset epilepsies
with medication-resistant seizures and poor developmental outcomes. Many epileptic …
with medication-resistant seizures and poor developmental outcomes. Many epileptic …
Common molecular mechanisms of SLC6A1 variant-mediated neurodevelopmental disorders in astrocytes and neurons
F Mermer, S Poliquin, K Rigsby, A Rastogi, W Shen… - Brain, 2021 - academic.oup.com
Solute carrier family 6 member 1 (SLC6A1) is abundantly expressed in the developing brain
even before the CNS is formed. Its encoded GABA transporter 1 (GAT-1) is responsible for …
even before the CNS is formed. Its encoded GABA transporter 1 (GAT-1) is responsible for …
The GABRG2 mutation, Q351X, associated with generalized epilepsy with febrile seizures plus, has both loss of function and dominant-negative suppression
JQ Kang, W Shen, RL Macdonald - Journal of Neuroscience, 2009 - Soc Neuroscience
The GABA A receptor γ2 subunit mutation, Q351X, associated with generalized epilepsy
with febrile seizures plus (GEFS+), created a loss of function with homozygous expression. …
with febrile seizures plus (GEFS+), created a loss of function with homozygous expression. …
Synaptic clustering differences due to different GABRB3 mutations cause variable epilepsy syndromes
YW Shi, QI Zhang, K Cai, S Poliquin, W Shen… - Brain, 2019 - academic.oup.com
GABRB3 is highly expressed early in the developing brain, and its encoded β3 subunit is
critical for GABA A receptor assembly and trafficking as well as stem cell differentiation in …
critical for GABA A receptor assembly and trafficking as well as stem cell differentiation in …
Phosphorylation and putative ER retention signals are required for protein kinase A-mediated potentiation of cardiac sodium current
J Zhou, HG Shin, J Yi, W Shen, CP Williams… - Circulation …, 2002 - Am Heart Assoc
Activation of protein kinase A (PKA) increases Na + current derived from the human cardiac
Na + channel, hH1, in a slow, nonsaturable manner. This effect is prevented by compounds …
Na + channel, hH1, in a slow, nonsaturable manner. This effect is prevented by compounds …