4-Methoxytoluquinone (VI) is transformed in twenty stages into dZ-9 (n) l6-bisdehydro-20-norprogesterone
(LXIV)(ca. 1 g./100 g. VI). This substance, the first totally synthetic non-…

A number of 3-carboxamides of2-alkyl-4-hydroxy-2i7-l, 2-benzothiazine 1, 1-dioxide were
synthesized and their antiinflammatory activity was investigated. A procedure for isomerizing …

A number of sulfamylureas of general structure RiR2NS02XHC0XHlt ltave been prepared
and screened for hypoglycemic activity in the rat. The more promising variations in the ILR2X …

Reaction of I in ether solution with excess diazo-methane gave the microbiologically active
methyl ester (II), crystallized from ether-hexane as color-less needles, mp 53-54,[a] 26D—50.9…

A series of substituted benzenedisulfonamide carbonicanhydrase inhibitors is described
and their anticonvulsant activities are listed. One compound, 4-(4-methoxypiperidinosulfonyl)-2-…

This paper is concerned with our characterization studies leading to elucidation of the structure
and to synthesis of the compound. I was isolated by solvent extraction of the fermentation …

In recent years, there has been widespread interest in sulphonyl-ureas because of the
hypoglycemic activity of some members of this class. 1™ 13 Two sulphonylureas are now in …

3H 4 I in vitro activity against Mycobacterium, tuberculosis led to the preparation and testing
of three types of closely related compounds:(1) 2-substituted-4-thiazolidones,(2) carboxyl …

Benzthiazide is an orally effective and highly potent nonmercurial diuretic and saluretic. In
comparison with chlorothiazide, it is 4 and 8 times more potent in dogs and rats, respectively, …

In connection with a research program on tertiary acetylenic carbinols as central nervous
system depressants, 1 we were interested in determining the effect of halogen substitution on …