To investigate the role of interleukin-5 (IL-5) on airway hyperreactivity and pulmonary
inflammation in nonhuman primate airways, the effect of a neutralizing monoclonal antibody to …

We have characterized desloratadine (5H-benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene),
CAS 100643-71-8) as a potent antagonist of the human …

Pulmonary inflammation with eosinophil (EOs) infiltration is a prominent feature of allergic
respiratory diseases such as asthma. In order to study the cellular response during the …

Interleukin-5 (IL-5) is important in the control of differentiation, migration, and activation of
eosinophils. In order to study the role of IL-5 in the development of eosinophilic inflammation of …

To investigate the role of IL-5 in airway hyperreactivity and pulmonary eosinophilia, we
used a model of allergic asthma in guinea pigs and a neutralizing monoclonal antibody (TRFK-5) …

Background Desloratadine is a non‐sedating, clinically effective, anti‐allergic therapy that
has been shown to exhibit anti‐inflammatory properties that extend beyond its ability to …

A novel class of antiallergy agents, thesubstituted 1, 8-naphthyridin-2 (Lff)-ones, is described.
The present compounds are orally active, potent inhibitors of allergicand nonallergic …

Mometasone furoate (MF, CAS 83919-23-7, Sch 32088), budesonide (BUD, CAS 51372-29-3),
fluticasone propionate (FP, CAS 80474-14-2), and triamcinolone acetonide (TA, CAS-76-…

… lungs of W/W' mice, we detected mast cells in the lungs of mast-cell-reconstituted W/W'
mice… in the lungs of nonsensitized and sensitized W/W' mice that had received bonemarrow-…

Interleukin (IL)-9 is a T-cell–derived cytokine with pleiotropic activities on T helper 2 cells, B
cells, and mast cells. IL-9 may therefore play an important role in the development of allergic …