Transmitter, ion channel and receptor properties of pheochromocytoma (PC12) cells: a model for neurotoxicological studies.

TJ Shafer, WD Atchison - Neurotoxicology, 1991 - europepmc.org
The increased desire to use in vitro techniques in neurotoxicology has resulted in the search
for clonal cell lines which may be useful for studying disruption by neurotoxicants of various …

Mechanisms of methylmercury‐induced neurotoxicity

WD Atchison, MF Hare - The FASEB journal, 1994 - Wiley Online Library
AtchisonWD, Hare, MF Mechanisms … (WD Atchison, unpublished …

The vascular system as a target of metal toxicity

…, JM Woods, A Barchowsky, WD Atchison - Toxicological …, 2008 - academic.oup.com
Vascular system function involves complex interactions among the vascular endothelium,
smooth muscle, the immune system, and the nervous system. The toxic metals cadmium (Cd), …

The role of environmental mercury, lead and pesticide exposure in development of amyotrophic lateral sclerosis

FO Johnson, WD Atchison - Neurotoxicology, 2009 - Elsevier
Exposure to an environmental toxicant as a risk factor in the development of amyotrophic
lateral sclerosis (ALS) was first hinted at (demonstrated) in the Chamorro indigenous people of …

Pathways Mediating Ca2+ Entry in Rat Cerebellar Granule Cells Followingin VitroExposure to Methyl Mercury

MS Marty, WD Atchison - Toxicology and applied pharmacology, 1997 - Elsevier
… 5), although v-CTxMVIIC only inhibited 35.4 { 4.18% of the rise in fluores(Hare and Atchison,
1995b) and have been shown to prevent Ca2/-mediated cytotoxicity in other cells, we …

Pyrethroids and their effects on ion channels

…, AP Neal, WD Atchison - Pesticides—Advances in …, 2012 - books.google.com
Ion channels are integral membrane proteins that are critical for neuronal function. They
form pores in the plasma membrane that allow certain ions to travel with their concentration …

Acute exposure to methylmercury opens the mitochondrial permeability transition pore in rat cerebellar granule cells

TL Limke, WD Atchison - Toxicology and applied pharmacology, 2002 - Elsevier
Cerebellar granule cells are preferentially targeted during methylmercury (MeHg) poisoning.
Following acute MeHg exposure, granule cells in culture undergo an increase in …

Elevations of intracellular Ca2+ as a probable contributor to decreased viability in cerebellar granule cells following acute exposure to methylmercury

MS Marty, WD Atchison - Toxicology and applied pharmacology, 1998 - Elsevier
… were isolated from 7-day-old Sprague–Dawley rats using a previously described protocol
(Marty and Atchison, 1997). Once removed, cerebella were digested for 15 min in 0.025% type …

Methylmercury affects multiple subtypes of calcium channels in rat cerebellar granule cells

JE Sirois, WD Atchison - Toxicology and applied pharmacology, 2000 - Elsevier
… , 1992), whole-cell Ba2 currents in pheochromocytoma (PC12) cells (Shafer and Atchison, …
at the neuromuscular junction (Atchison and Narahashi, 1982; Atchison, 1986). Neonatal …

Acute Exposure to Methylmercury Causes Ca2+ Dysregulation and Neuronal Death in Rat Cerebellar Granule Cells through an M3 Muscarinic Receptor-Linked …

TL Limke, JJ Bearss, WD Atchison - Toxicological Sciences, 2004 - academic.oup.com
Acute exposure to low concentrations of methylmercury (MeHg) causes a severe loss of
intracellular calcium ( \batchmode \documentclass[fleqn,10pt,legalpaper]{article} \usepackage{…