Characterization of Nebulized Liposomal Amikacin (Arikace) as a Function of Droplet Size

…, JK Lee, VS Malinin, S Durwas-Krishnan… - Journal of aerosol …, 2008 - liebertpub.com
The stress of nebulization has been shown to alter the properties of liposomal drugs. What
has not been demonstrated is whether nebulized liposomes differ as a function of droplet size…

[HTML][HTML] Osmotic and curvature stress affect PEG-induced fusion of lipid vesicles but not mixing of their lipids

VS Malinin, P Frederik, BR Lentz - Biophysical journal, 2002 - cell.com
Poly (ethylene glycol) (PEG) in the external environment of membrane vesicles creates
osmotic imbalance that leads to mechanical stress in membranes and may induce local …

[HTML][HTML] Energetics of vesicle fusion intermediates: comparison of calculations with observed effects of osmotic and curvature stresses

VS Malinin, BR Lentz - Biophysical journal, 2004 - cell.com
We reported previously the effects of both osmotic and curvature stress on fusion between
poly(ethylene glycol)-aggregated vesicles. In this article, we analyze the energetics of fusion …

Inhaled treprostinil-prodrug lipid nanoparticle formulations provide long-acting pulmonary vasodilation

…, Z Li, RW Chapman, WR Perkins, VS Malinin - Drug …, 2018 - thieme-connect.com
Treprostinil (TRE), a prostanoid analogue approved in the USA for the treatment of pulmonary
arterial hypertension, requires continuous infusion or multiple dosing sessions per day for …

[HTML][HTML] Strategies to overcome biological barriers associated with pulmonary drug delivery

AJ Plaunt, TL Nguyen, MR Corboz, VS Malinin… - Pharmaceutics, 2022 - mdpi.com
While the inhalation route has been used for millennia for pharmacologic effect, the biological
barriers to treating lung disease created real challenges for the pharmaceutical industry …

The rate of lipid transfer during fusion depends on the structure of fluorescent lipid probes: a new chain-labeled lipid transfer probe pair

VS Malinin, ME Haque, BR Lentz - Biochemistry, 2001 - ACS Publications
A number of fluorescent probes have been used to follow membrane fusion events, particularly
intermixing of lipids. None of them is ideal. The most popular pair of probes is NBD-PE …

[HTML][HTML] An overview of the biology of a long-acting inhaled treprostinil prodrug

RW Chapman, MR Corboz, VS Malinin… - Pulmonary …, 2020 - Elsevier
Treprostinil (TRE) is a prostanoid analog pulmonary vasodilator drug marketed with
subcutaneous, intravenous (iv), oral, and inhaled routes of administration for the treatment of …

Development and preclinical evaluation of new inhaled lipoglycopeptides for the treatment of persistent pulmonary methicillin-resistant staphylococcus aureus …

…, D Cipolla, WR Perkins, VS Malinin… - Antimicrobial Agents …, 2021 - Am Soc Microbiol
Chronic pulmonary methicillin-resistant Staphylococcus aureus (MRSA) disease in cystic
fibrosis (CF) has a high probability of recurrence following treatment with standard-of-care …

[HTML][HTML] Development and characterization of treprostinil palmitil inhalation aerosol for the investigational treatment of pulmonary arterial hypertension

…, Z Li, DC Cipolla, WR Perkins, VS Malinin - International Journal of …, 2021 - mdpi.com
Treprostinil palmitil (TP) is a prodrug of treprostinil (TRE), a pulmonary vasodilator that has
been previously formulated for inhaled administration via a nebulizer. TP demonstrates a …

Airway deposition and retention of liposomal amikacin for inhalation in patients with pulmonary nontuberculous mycobacterial disease

…, R Gupta, TE Corcoran, VS Malinin… - … DISEASE AND CASE …, 2016 - atsjournals.org
Purpose: bronchiectasis (NCFB). In a recent clinical trial targeting treatment refractory
pulmonary NTM disease (PNTMD), liposomal amikacin for inhalation (LAI) was associated with …