This monograph narrates not only the theoretical aspects and experimental data, but also
outlines new approaches to the prevention of aging and age-related pathology, thus …

Protein machines and lipid bilayers both play central roles in cell membrane fusion, a process
crucial to life. Recent results provide clues to how both components function in fusion. …

The stress of nebulization has been shown to alter the properties of liposomal drugs. What
has not been demonstrated is whether nebulized liposomes differ as a function of droplet size…

Poly (ethylene glycol) (PEG) in the external environment of membrane vesicles creates
osmotic imbalance that leads to mechanical stress in membranes and may induce local …

We reported previously the effects of both osmotic and curvature stress on fusion between
poly(ethylene glycol)-aggregated vesicles. In this article, we analyze the energetics of fusion …

Treprostinil (TRE), a prostanoid analogue approved in the USA for the treatment of pulmonary
arterial hypertension, requires continuous infusion or multiple dosing sessions per day for …

Idiopathic pulmonary fibrosis is a progressive and lethal disease and while there are now
two approved drugs (Esbriet ® and Ofev ® ) additional effective treatments are still needed. …

While the inhalation route has been used for millennia for pharmacologic effect, the biological
barriers to treating lung disease created real challenges for the pharmaceutical industry …

This article describes the preclinical pharmacology and pharmacokinetics (PK) of hexadecyl-treprostinil
(C16TR), a prodrug of treprostinil (TRE), formulated in a lipid nanoparticle (LNP) …

Pulmonary nontuberculous mycobacterial (PNTM) infections represent a treatment challenge.
Liposomal amikacin for inhalation (LAI) is a novel formulation currently in development for …