The toxicity of ionizing radiation is associated with massive apoptosis in radiosensitive organs.
Here, we investigate whether a drug that activates a signaling mechanism used by tumor …

Factors that mediate p53 tumor suppressor activity remain largely unknown. In this study we
describe a systematic approach to identify downstream mediators of tumor suppressor …

PURPOSE: Development of mucositis is a frequent side effect of radiotherapy of patients with
head-and-neck cancer. We have recently reported that bacterial flagellin, an agonist of Toll-…

Given an ever-increasing risk of nuclear and radiological emergencies, there is a critical
need for development of medical radiation countermeasures (MRCs) that are safe, easily …

There are urgent needs to establish capability to rapidly assess radiation injury in mass
casualty and population monitoring scenarios. This study's objective was to evaluate several …

p53 tumor suppressor gene controls cell response to a variety of stresses inducing growth
arrest or apoptosis in damaged cells. It largely determines the sensitivity of tumor and normal …

There are currently no approved medical radiation countermeasures (MRC) to reduce the
lethality of high-dose total body ionizing irradiation expected in nuclear emergencies. An ideal …

Although prostate-specific antigen (PSA) is considered a uniquely important tumor marker
and is broadly used for early detection of prostate cancer, the molecular mechanisms …

Chronic inflammation is known to promote cancer, suggesting that negative regulation of
inflammation is likely to be tumor suppressive. We found that p53 is a general inhibitor of …

Given an ever-increasing risk of nuclear and radiological emergencies, there is a critical
need for development of medical radiation countermeasures (MRC) that are safe, easily …