The mammalian family X DNA polymerases (DNA polymerases β, λ, μ, and TdT) contribute
to base excision repair and double-strand break repair by virtue of their ability to fill short …

An aerobic environment burdens DNA polymerase substrates with oxidized substrates (DNA
and nucleotide pools). A major promutagenic lesion resulting from oxidative stress is 8-oxo-…

Potato can be propagated sexually (by botanical seed, also called true potato seed) and
asexually (vegetative) by means of tubers. Seed potato tubers are utilized for multiplication and …

The molecular details of the nucleotidyl transferase reaction have remained speculative, as
strategies to trap catalytic intermediates for structure determination utilize substrates lacking …

An equation for the rate of capillary rise in porous media with nonuniform pores has been
derived on the basis of a three-dimensional network model of pore structure, consisting of a …

We report the crystallographic structures of DNA polymerase β with dG-dAMPCPP and dC-dAMPCPP
mismatches in the active site. These premutagenic structures were obtained with a …

Aims The primary aims of these two single‐centre, randomized, evaluator‐blind, placebo/positive‐controlled,
parallel‐group studies were to evaluate the potential for pharmacodynamic …

Background: Ezetimibe, a selective inhibitor of intestinal cholesterol absorption, is in clinical
development for the treatment of hypercholesterolemia. It is rapidly absorbed and …

Porous materials occur in great variety, both in na-ture and in industry. Living organisms are
all porous; their life functions would not be possible without pores in them. Pores make …

DNA polymerase catalysis and fidelity studies typically compare incorporation of “right” versus
“wrong” nucleotide bases where the leaving group is pyrophosphate. Here we use dGTP …