Spontaneous chemical degradation of substance P in the solid phase and in solution
UWE KERTSCHER, M BIENERT… - … journal of peptide …, 1993 - Wiley Online Library
The instability of the undecapeptide substance P (SP), a neuropeptide implicated in several
physiological processes, was occasionally observed when the peptide was stored in the …
physiological processes, was occasionally observed when the peptide was stored in the …
Liquid chromatography/mass spectrometry of peptides of biological samples
B Mehlis, U Kertscher - Analytica Chimica Acta, 1997 - Elsevier
This review is focused on the Chromatographic methods of liquid chromatography-mass
spectrometry (LC-MS) applied in the analysis of peptides in biological/biochemical samples. In …
spectrometry (LC-MS) applied in the analysis of peptides in biological/biochemical samples. In …
Identification and measurement of β-endorphin levels in the skin during induced hair growth in mice
…, S Eichmüller, B Mehlis, U Kertscher… - … et Biophysica Acta (BBA …, 1997 - Elsevier
We describe new and effective techniques for extracting proopiomelanocortin (POMC)-derived
peptides from mammalian skin. Using this methodology (hot-acid extraction) and two …
peptides from mammalian skin. Using this methodology (hot-acid extraction) and two …
Liquid chromatographic-mass spectrometric studies on the enzymatic degradation of gonadotropin-releasing hormone
M Brudel, U Kertscher, H Berger, B Mehlis - Journal of Chromatography A, 1994 - Elsevier
Gonadotropin-releasing hormone (GnRH) derivatives are used in cancer therapy, but
relatively little is known about their metabolic fate in the organism. This paper describes the …
relatively little is known about their metabolic fate in the organism. This paper describes the …
Gonadotropin-releasing hormone (GnRH) analogs: relationship between their structure, proteolytic inactivation and pharmacokinetics in rats
H Berger, N Heinrich, E Albrecht, U Kertscher… - Regulatory peptides, 1991 - Elsevier
There are two types of superactive agonists of gonadotropin-releasing hormone (GnRHa-I: (d-amino
acid) 6 -GnRH and GnRHa-II: (d-amino acid) 6 -(desGly) 10 -GnRH-ethylamide) the …
acid) 6 -GnRH and GnRHa-II: (d-amino acid) 6 -(desGly) 10 -GnRH-ethylamide) the …
Disposition of the 3H-labeled gonadotropin-releasing hormone analog buserelin in rats.
…, J Sandow, N Heinrich, E Albrecht, U Kertscher… - Drug metabolism and …, 1993 - ASPET
The short-time disposition of 3H-labeled D-Ser(TBU)6-desGly10-GnRH-ethylamide ([3H]buserelin)
was studied in rats after bolus intravenous and subcutaneous injections and killing …
was studied in rats after bolus intravenous and subcutaneous injections and killing …
The enzymatic degradation of bradykinin in semen of various species
…, A Böttger, WE Siems, M Rottmann, U Kertscher - Andrologia, 1994 - Wiley Online Library
The degradation of bradykinin in semen and on washed sperm cells of various species (human,
pig, cattle, sheep) is mainly controlled by two peptidases, the angiotensin‐converting …
pig, cattle, sheep) is mainly controlled by two peptidases, the angiotensin‐converting …
Degradation of bradykinin in semen of ram and boar
A Boettger, U Kertscher, C Steinmann, U Baeger… - Biochemical …, 1993 - Elsevier
… (k,, was estimated from the optimum of our u/S characteristic which was only 0.46 x V,,,,,.) …
u is the rate of BK degradation as estimated from HPLC whereby quantitation was achieved by …
u is the rate of BK degradation as estimated from HPLC whereby quantitation was achieved by …
The degradation of corticotropin-releasing factor by enzymes of the rat brain studied by liquid chromatography–mass spectrometry
U Kertscher, M Beyermann, E Krause, J Furkert… - Peptides, 1998 - Elsevier
The corticotropin-releasing factor (CRF; 41 amino acid residues) is a major regulatory
peptide in the response to stress and is distributed over many regions of the brain. We have …
peptide in the response to stress and is distributed over many regions of the brain. We have …
Pathways of degradation of buserelin by rat kidney membrane.
U Kertscher, M Brudel, B Mehlis, J Sandow… - Journal of Pharmacology …, 1995 - ASPET
The pathways of in vitro degradation of the gonadotropin-releasing hormone (GnRH) analog
buserelin [pGlu-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg- ProNHEt, B1-9] by the rat kidney …
buserelin [pGlu-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg- ProNHEt, B1-9] by the rat kidney …