Diminished function and expression of the cardiac Na+‐Ca2+ exchanger in diabetic rats: implication in Ca2+ overload

Y Hattori, N Matsuda, J Kimura, T Ishitani… - The Journal of …, 2000 - Wiley Online Library
1 The present work was carried out in order to determine whether a decrease in cardiac Na
+ ‐Ca 2+ exchanger (NCX) activity observed in diabetes is caused by a reduction in NCX …

Combined activation of coagulation and inflammation has an important role in multiple organ dysfunction and poor outcome after severe trauma

…, N Matsuda, M Hayakawa, T Ishitani… - Thrombosis and …, 2002 - thieme-connect.com
We tested the hypothesis that activated neutrophil-endothelial cell interaction in DIC can
cause endothelial injury contributing to multiple organ dysfunction syndrome (MODS) and a …

Tissue factor pathway inhibitor response does not correlate with tissue factor-induced disseminated intravascular coagulation and multiple organ dysfunction …

S Gando, S Nanzaki, Y Morimoto, T Ishitani… - Critical care …, 2001 - journals.lww.com
Objective To determine the precise relationship between tissue factor and tissue factor pathway
inhibitor (TFPI) after trauma, as well as to test the hypothesis that low TFPI levels are not …

Pharmacokinetics and the most suitable dosing regimen of fluconazole in critically ill patients receiving continuous hemodiafiltration

…, S Gando, N Matsuda, T Kameue, T Ishitani… - Intensive care …, 2003 - Springer
Objective To evaluate fluconazole pharmacokinetics and the dosage best suited to maintain
effective plasma concentration in patients with continuous hemodiafiltration. Design and …

Imbalances between the levels of tissue factor and tissue factor pathway inhibitor in ARDS patients

…, N Matsuda, M Hayakawa, Y Morimoto, T Ishitani… - Thrombosis research, 2003 - Elsevier
Introduction: To evaluate the pathogenetic role of tissue factor (TF), tissue factor pathway
inhibitor (TFPI), and neutrophil elastase in acute respiratory distress syndrome (ARDS), as well …

Pharmacokinetics of teicoplanin in critically ill patients undergoing continuous hemodiafiltration

…, S Gando, N Matsuda, T Kameue, T Ishitani… - Intensive care …, 2003 - Springer
Teicoplanin which is structurally related to vancomycin is a glycopeptide antibiotic and has
considerable pharmacokinetic differences over vancomycin in terms of its longer elimination …

Synbiotic therapy reduces the pathological gram-negative rods caused by an increased acetic acid concentration in the gut

M Hayakawa, T Asahara, T Ishitani, A Okamura… - Digestive diseases and …, 2012 - Springer
Background The mechanisms for the improvement of the gut flora and the intestinal environment
by synbiotic therapy are unclear. Aims This study evaluated the changes in the gut flora …

Effects of Ca2+ sensitizers on contraction,[Ca2+] i transient and myofilament Ca2+ sensitivity in diabetic rat myocardium: potential usefulness as inotropic agents

T Ishitani, Y Hattori, F Sakuraya, H Onozuka… - … of Pharmacology and …, 2001 - ASPET
The purpose of the present study was to investigate the effects of Ca 2+ sensitizers EMD
57033, MCI-154, and EGIS-9377 in cardiac preparations from streptozotocin-induced diabetic …

Cardiac profile of EGIS-9377, a novel cardiotonic agent as a Ca2+ sensitizer with bradycardiac activity

Y Hattori, T Ishitani, F Tomita, S Gando… - Naunyn-Schmiedeberg's …, 1999 - Springer
The cardiac profile of EGIS-9377 {2-(1-methylthio)-5-(2-morpholinoethylamino)-8,9-dihydro-7H-thiopyrano[3,2-d][1,2,4]triazolo[1,5-a]pyrimidine
dihydrochloride}, a newly synthesized …

Circulating endotoxin and (1→ 3)-β-D-glucan levels during cardiopulmonary bypass and living donor orthotopic liver transplantation clinical and experimental …

S Gando, T Ishitani, T Kojima, K Ito… - Journal of the …, 2005 - jstage.jst.go.jp
[目的] 人工心肺手術および生体肝移植手術中にリムルステストが陽性となる. これがエンドトキシン
によるのか (1→ 3)-β-D-グルカン (以下 β-D-グルカン) によるのかを確認して, その原因を究明する…