KGA-2727, a novel selective inhibitor of a high-affinity sodium glucose cotransporter (SGLT1), exhibits antidiabetic efficacy in rodent models

T Shibazaki, M Tomae, Y Ishikawa-Takemura… - … of Pharmacology and …, 2012 - ASPET
The high-affinity sodium glucose cotransporter (SGLT1) plays a critical role in glucose
absorption from the gastrointestinal tract. We have developed 3-(3-{4-[3-(β-d-glucopyranosyloxy)-5…

Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes

…, H Shimojo, T Shibazaki… - American Journal …, 2011 - journals.physiology.org
In some forms of cardiac hypertrophy and failure, the gain of Ca 2+ -induced Ca 2+ release [CICR;
ie, the amount of Ca 2+ released from the sarcoplasmic reticulum normalized to Ca 2…

Structure–activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) …

…, K Ohno, T Miyagi, F Itoh, T Shibazaki… - Bioorganic & medicinal …, 2012 - Elsevier
Sodium glucose co-transporter 1 (SGLT1) plays a dominant role in the absorption of
glucose in the gut and is considered a promising target in the development of treatments for …

Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in langendorff-perfused guinea-pig hearts

M Hirose, T Shibazaki, T Nakada… - Biological and …, 2014 - jstage.jst.go.jp
Phlorizin is a type of flavonoids and has a peroxynitrite scavenging effect. This study aimed
to elucidate the effects of phlorizin on ischemia-induced ventricular tachyarrhythmia (VT). …

Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca2+ channel activity through phosphatases in heart failure

…, S Gomi, T Shibazaki… - American Journal …, 2012 - journals.physiology.org
L-type Ca 2+ channels (LTCCs) play an essential role in the excitation-contraction coupling
of ventricular myocytes. We previously found that t-tubular (TT) LTCC current density was …

Design, synthesis, and structure–activity relationships of a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-yl β-d-glycopyranosides substituted with novel hydrophilic …

…, K Ohno, T Miyagi, F Itoh, T Shibazaki… - Bioorganic & medicinal …, 2013 - Elsevier
Sodium glucose co-transporter 1 (SGLT1) plays a dominant role in the absorption of glucose
in the gut and is considered a promising target in the development of therapeutic options for …

Two mechanistically distinct effects of dihydropyridine nifedipine on CaV1. 2 L-type Ca2+ channels revealed by Timothy syndrome mutation

…, M Kobayashi, T Kashihara, T Shibazaki… - European journal of …, 2012 - Elsevier
Dihydropyridine Ca 2+ channel antagonists (DHPs) block Ca V 1.2 L-type Ca 2+ channels (LTCCs)
by stabilizing their voltage-dependent inactivation (VDI); however, it is still not clear …

The proximal C-terminus of α1C subunits is necessary for junctional membrane targeting of cardiac L-type calcium channels

…, T Kashihara, X Sheng, T Shibazaki… - Biochemical …, 2012 - portlandpress.com
In cardiac myocytes, LTCCs (L-type calcium channels) form a functional signalling complex
with ryanodine receptors at the JM (junctional membrane). Although the specific localization …

Phlorizin Prevents Ischemia-induced Ventricular Tachyarrhythmia in Langendorff-perfused Guinea Pig Hearts

M Hirose, T Nakada, T Shibazaki, T Kashihara… - 2009 - Am Heart Assoc
Introduction: Myocardial ischemia increases intracellular Na + concentration leading to intra-cellular
Ca 2+ overload, which increases the left ventricular end diastolic pressure (LVEDP) …

Articles in PresS. Am J Physiol Heart Circ Physiol (December 30, 2010). doi: 10.1152/ajpheart. 00508.2010

TS Shimojo, X Sheng, S Yano… - Am J Physiol Heart …, 2010 - journals.physiology.org
In some forms of cardiac hypertrophy and failure, a gain of Ca2+-induced Ca2+ release 24 (CICR)(ie
the amount of Ca2+ released from the sarcoplasmic reticulum normalized to Ca2+ …