RNA interference (RNAi) is a mechanism by which double-stranded RNAs (dsRNAs) suppress
specific transcripts in a sequence-dependent manner. dsRNAs are processed by Dicer to …

Silencing of transposable elements occurs during fetal gametogenesis in males via de novo
DNA methylation of their regulatory regions. The loss of MILI (miwi-like) and MIWI2 (mouse …

Colorectal cancer is a major cause of death in Japan, where it accounts for the largest number
of deaths from malignant neoplasms in women and the third largest number in men. Many …

Japanese mortality due to colorectal cancer is on the rise, surpassing 49,000 in 2015. Many
new treatment methods have been developed during recent decades. The Japanese …

Background Adjuvant chemotherapy improves survival among patients with stage III colon
cancer, but no reliable molecular predictors of outcome have been identified. Methods We …

Human colorectal tumors bear recurrent mutations in genes encoding proteins operative in
the WNT, MAPK, TGF-β, TP53 and PI3K pathways 1 , 2 . Although these pathways influence …

Background Since 2004, a regimen of 6 months of treatment with oxaliplatin plus a fluoropyrimidine
has been standard adjuvant therapy in patients with stage III colon cancer. However, …

A long-term goal of cancer diagnosis is to develop tumor-imaging techniques that have
sufficient specificity and sensitivity. To achieve this goal, minimizing the background signal …

Background Depth of submucosal invasion (SM depth) in submucosal invasive colorectal
carcinoma (SICC) is considered an important predictive factor for lymph node metastasis. …

The anti-ischemic effects and a possible mechanism of a new antistroke agent, 3-methyl-i-phenyl-pyrazolin-5-one(MCI-i
86), were studied. Preischemic treatment with MCI-i 86 (3 mg/kg …