Comparison of the amino acid sequence of rat liver NADPH-cytochrome P-450 oxidoreductase
with that of flavoproteins of known three-dimensional structure suggested that residues …

… D. vulgaris and Clostridium MP show that the flavin is positioned between Trp-60 and Tyr-98
in the D… in the sequence alignment of Figure 2; the D. vulgaris positions are indicated with …

Cytochrome b 5 , a 17‐kDa hemeprotein associated primarily with the endoplasmic
reticulum of eukaryotic cells, has long been known to augment some cytochrome P450 …

Policosanol is a mixture of long-chain primary alcohols that has been shown to decrease
serum cholesterol in animals and in humans. The hypocholesterolemic effect results from a …

Although extracts of garlic inhibit cholesterol biosynthesis in cultured hepatocytes, the
inhibitory components of garlic and the site or sites of inhibition in the cholesterol biosynthetic …

This is a report on a symposium sponsored by the American Society for Pharmacology and
Experimental Therapeutics and held at the Experimental Biology 2012 meeting in San Diego, …

The cDNA for human squalene monooxygenase, a key enzyme in the committed pathway
for cholesterol biosynthesis, was amplified from a human liver cDNA library and cloned, and …

Squalene monooxygenase is a flavin adenine dinucleotide-containing, microsomal enzyme
that catalyzes the second step in the committed pathway for cholesterol biosynthesis. …

The coding nucleotide sequence of the mRNA for NADPH-cytochrome P-450 oxidoreductase
(NADPH:ferricytochrome oxidoreductase, EC 1.6.2.4) from rat liver was determined from …

We have expressed in Escherichia coli a cDNA encoding rabbit liver cytochrome P-450IIE1,
the ethanol-inducible P-450. The expressed P-450 is located primarily in the bacterial inner …