Adenosine inhibits tumor necrosis factor-α release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor
LM Kreckler, TC Wan, ZD Ge, JA Auchampach - Journal of Pharmacology …, 2006 - ASPET
Adenosine is elaborated in injured tissues where it suppresses inflammatory responses of
essentially all immune cells, including production of proinflammatory cytokines such as tumor …
essentially all immune cells, including production of proinflammatory cytokines such as tumor …
Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor
JA Auchampach, X Jin, TC Wan, GH Caughey… - Molecular …, 1997 - ASPET
We cloned and characterized the canine A 3 adenosine receptor (AR) and examined AR-induced
degranulation of the BR line of canine mastocytoma cells. Canine A 3 AR transcript is …
degranulation of the BR line of canine mastocytoma cells. Canine A 3 AR transcript is …
Structure-Guided Design of A3 Adenosine Receptor-Selective Nucleosides: Combination of 2-Arylethynyl and Bicyclo[3.1.0]hexane Substitutions
…, F Deflorian, K Phan, ZG Gao, TC Wan… - Journal of medicinal …, 2012 - ACS Publications
(N)-Methanocarba adenosine 5′-methyluronamides containing known A 3 AR (adenosine
receptor)-enhancing modifications, ie, 2-(arylethynyl)adenine and N 6 -methyl or N 6 -(3-…
receptor)-enhancing modifications, ie, 2-(arylethynyl)adenine and N 6 -methyl or N 6 -(3-…
Hypothermia in mouse is caused by adenosine A1 and A3 receptor agonists and AMP via three distinct mechanisms
…, S Jain, E Gizewski, TC Wan, DK Tosh, C Xiao… - …, 2017 - Elsevier
Small mammals have the ability to enter torpor, a hypothermic, hypometabolic state,
allowing impressive energy conservation. Administration of adenosine or adenosine 5'-…
allowing impressive energy conservation. Administration of adenosine or adenosine 5'-…
Cl-IB-MECA [2-Chloro-N6-(3-iodobenzyl) adenosine-5′-N-methylcarboxamide] Reduces Ischemia/Reperfusion Injury in Mice by Activating the A Adenosine …
ZD Ge, JN Peart, LM Kreckler, TC Wan… - … of Pharmacology and …, 2006 - ASPET
We used pharmacological agents and genetic methods to determine whether the potent A 3
adenosine receptor (AR) agonist 2-chloro-N 6 -(3-iodobenzyl)adenosine-5′-N-…
adenosine receptor (AR) agonist 2-chloro-N 6 -(3-iodobenzyl)adenosine-5′-N-…
Induction of immune responses to ovarian tumor antigens by multiparity
…, Ç Gerçel-Taylor, CM Yashar, TC Wan… - The Journal of the …, 1997 - Springer
Objective Because epidemiologic data indicate a reduction in ovarian cancer risk with
increased parity, the occurrence of maternal immunization against ovarian tumor-associated …
increased parity, the occurrence of maternal immunization against ovarian tumor-associated …
IL-13 promotes in vivo neonatal cardiomyocyte cell cycle activity and heart regeneration
DJ Wodsedalek, SJ Paddock, TC Wan… - American Journal …, 2019 - journals.physiology.org
There is great interest in identifying signaling mechanisms by which cardiomyocytes (CMs)
can enter the cell cycle and promote endogenous cardiac repair. We have previously …
can enter the cell cycle and promote endogenous cardiac repair. We have previously …
Activation of the A3 adenosine receptor suppresses superoxide production and chemotaxis of mouse bone marrow neutrophils
D van der Hoeven, TC Wan, JA Auchampach - Molecular pharmacology, 2008 - ASPET
Adenosine is formed in injured/ischemic tissues, where it suppresses the actions of essentially
all cells of the immune system. Most of the anti-inflammatory actions of adenosine have …
all cells of the immune system. Most of the anti-inflammatory actions of adenosine have …
A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophils
D van der Hoeven, TC Wan, ET Gizewski… - … of Pharmacology and …, 2011 - ASPET
The formation of adenosine dampens inflammation by inhibiting most cells of the immune
system. Among its actions on neutrophils, adenosine suppresses superoxide generation and …
system. Among its actions on neutrophils, adenosine suppresses superoxide generation and …
The A3 adenosine receptor agonist CP-532,903 [N6-(2, 5-dichlorobenzyl)-3′-aminoadenosine-5′-N-methylcarboxamide] protects against myocardial ischemia …
TC Wan, ZD Ge, A Tampo, Y Mio… - … of Pharmacology and …, 2008 - ASPET
We examined the cardioprotective profile of the new A 3 adenosine receptor (AR) agonist
CP-532,903 [N 6 -(2,5-dichlorobenzyl)-3′-aminoadenosine-5′-N-methylcarboxamide] in an …
CP-532,903 [N 6 -(2,5-dichlorobenzyl)-3′-aminoadenosine-5′-N-methylcarboxamide] in an …