Neural correlates of the LSD experience revealed by multimodal neuroimaging

…, R Leech, LT Williams, TM Williams… - Proceedings of the …, 2016 - National Acad Sciences
Lysergic acid diethylamide (LSD) is the prototypical psychedelic drug, but its effects on the
human brain have never been studied before with modern neuroimaging. Here, three …

Broadband cortical desynchronization underlies the human psychedelic state

…, RJ Moran, MJ Brookes, TM Williams… - Journal of …, 2013 - Soc Neuroscience
Psychedelic drugs produce profound changes in consciousness, but the underlying
neurobiological mechanisms for this remain unclear. Spontaneous and induced oscillatory activity …

Functional connectivity measures after psilocybin inform a novel hypothesis of early psychosis

…, R Leech, D Erritzoe, TM Williams… - Schizophrenia …, 2013 - academic.oup.com
Psilocybin is a classic psychedelic and a candidate drug model of psychosis. This study
measured the effects of psilocybin on resting-state network and thalamocortical functional …

[HTML][HTML] The effects of acutely administered 3, 4-methylenedioxymethamphetamine on spontaneous brain function in healthy volunteers measured with arterial spin …

…, A Sethi, MAP Bloomfield, TM Williams, M Bolstridge… - Biological …, 2015 - Elsevier
Background The compound 3,4-methylenedioxymethamphetamine (MDMA) is a potent
monoamine releaser that produces an acute euphoria in most individuals. Methods In a double-…

The effect of acutely administered MDMA on subjective and BOLD-fMRI responses to favourite and worst autobiographical memories

…, M Tanner, M Bloomfield, TM Williams… - International Journal …, 2014 - academic.oup.com
3,4-methylenedioxymethamphetamine (MDMA) is a potent monoamine-releaser that is
widely used as a recreational drug. Preliminary work has supported the potential of MDMA in …

[HTML][HTML] Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers

N Family, EL Maillet, LTJ Williams, E Krediet… - …, 2020 - Springer
Abstract Research has shown that psychedelics, such as lysergic acid diethylamide (LSD),
have profound anti-inflammatory properties mediated by 5-HT 2A receptor signaling, …

First study of safety and tolerability of 3, 4-methylenedioxymethamphetamine-assisted psychotherapy in patients with alcohol use disorder

…, C Sakal, D Titheradge, TM Williams… - Journal of …, 2021 - journals.sagepub.com
Background: 3,4-methylenedioxymethamphetamine (MDMA) therapy has qualities that make
it potentially well suited for patients with addictions, but this has never been explored in a …

[HTML][HTML] Study protocol for “Psilocybin as a treatment for anorexia nervosa: a pilot study”

…, FJC de Magalhães, KL Alderton, TM Williams… - Frontiers in …, 2021 - frontiersin.org
… Alderton 1 Tim M. Williams Tim M. Williams 1 Allan Blemings Allan Blemings 1 Adele Lafrance
Adele Lafrance 3 Dasha E. Nicholls Dasha E. Nicholls 4 David Erritzoe David Erritzoe 1 …

The administration of psilocybin to healthy, hallucinogen-experienced volunteers in a mock-functional magnetic resonance imaging environment: a preliminary …

RL Carhart-Harris, TM Williams… - Journal of …, 2011 - journals.sagepub.com
This study sought to assess the tolerability of intravenously administered psilocybin in
healthy, hallucinogen-experienced volunteers in a mock-magnetic resonance imaging …

Brain opioid receptor binding in early abstinence from alcohol dependence and relationship to craving: an [11C] diprenorphine PET study

TM Williams, SJC Davies, LG Taylor… - European …, 2009 - Elsevier
The importance of the opioid receptor system in substance dependence is increasingly
recognised. We used PET with the non-selective tracer [ 11 C]diprenorphine to examine opioid …