The mechanism of activation of transglutaminase 2 (TG2) in the extracellular matrix remains
a fundamental mystery in our understanding of the biology of this multifunctional mammalian …

A number of lines of evidence suggest that transglutaminase 2 (TG2) may be one of the
earliest disease-relevant proteins to encounter immunotoxic gluten in the celiac gut. These and …

Previous studies in human patients and animal models have suggested that transglutaminase
2 (TG2) is upregulated in pulmonary hypertension (PH), a phenomenon that appears to …

Whereas the role of mammalian thioredoxin (Trx) as an intracellular protein cofactor is widely
appreciated, its function in the extracellular environment is not well-understood. Only few …

OBJECTIVES: Histological examination of duodenal biopsies is the gold standard for
assessing intestinal damage in celiac disease (CD). A noninvasive marker of disease status is …

A volumetric apparatus to measure hydrogen adsorption and desorption at room temperature
and up to 100 atm has been constructed and studied for accuracy, reproducibility, and …

The mechanism for activation of extracellular transglutaminase 2 (TG2) in the small intestine
remains a fundamental mystery in our understanding of celiac sprue pathogenesis. Using …

Introduction: Epidermal growth receptor (EGFR) is the most expressed membrane oncogenic
protein in human cancers. KRAS and BRAF mutations are significant drivers of resistance …

Celiac disease (CD; celiac sprue) is a widespread inflammatory disease of the small intestine.
The primary genetic (HLA-DQ2 or, less frequently,-DQ8) and environmental (dietary gluten…

• Phage displaying peptide libraries were screened for binding to surface-immobilized anti-CD3
scFv.• After several bind, elute, and amplify cycles, clonal phages were screened for …