While P-glycoprotein (PGP, ABCB1) is known to play an important role in drug exclusion at
the blood brain barrier (BBB), less is known about the contribution of other members in the …

PURPOSE: To quantify vitreous amino acid concentrations in pressure-induced retinal
ischemia and to evaluate the neuroprotective effect of memantine, a N-methyl-D-aspartate (NMDA…

Purpose: Gabapentin (GBP) is a commonly used drug in the treatment of partial seizures,
but its mode of action is still unclear. The genesis of seizures in temporal lobe epilepsy is …

BACKGROUND: In contrast to the abundance of seizure outcome reports in epilepsy surgery
for glioneuronal tumors in childhood and adolescence, there is a dearth of information …

Chronic renal failure (CRF) is associated with multiple hypothalamic dysfunctions, including
reduced secretion of gonadotropin-releasing hormone (GnRH). Because GnRH release is …

N‐methyl‐D‐aspartate (NMDA) receptors are composed of subunits from two families: NR1
and NR2. We used a dual‐label in situ hybridization technique to assess the levels of NR1 …

Members of the cytochrome P450 (P450) family of drug-metabolizing enzymes are present
in the human brain, and they may have important roles in the oxidation of endogenous …

The hyperpolarization‐activated current (I h ) contributes to intrinsic properties and network
responses of neurons. Its biophysical properties depend on the expression profiles of the …

As one of the best studied photoswitches, spiropyrans (SPs) have attracted significant
interest in the scientific community. Among the many stimuli to alter the isomerization into the …

We investigated the affinity of putative endocannabinoids (2-arachidonylglycerol, 2-AG; noladin
ether, virodhamine) for the human neocortical CB 1 receptor. Functional activity of these …