Radiation resistance in a subset of prostate tumors remains a challenge to prostate cancer
radiotherapy. The current study on the effects of radiation on prostate cancer cells reveals that …

Escape of prostate cancer (PCa) cells from ionizing radiation–induced (IR-induced) killing
leads to disease progression and cancer relapse. The influence of sphingolipids, such as …

Bioactive sphingolipids, such as ceramide, sphingosine and sphingosine-1-phosphate are
known bio-effector molecules which play important roles in various aspects of cancer biology …

6-Methoxygossypol and 6,6′-dimethoxygossypol were recently isolated from the root tissue
of cotton plants. Together with gossypol, these natural products were investigated for a …

Invasiveness is one of the key features of aggressive prostate cancer; however, our
understanding of the precise mechanisms effecting invasion remains limited. The ceramide …

Background Our objective was to evaluate the outcomes of metastatic head and neck
squamous cell carcinoma (HNSCC) by disease burden with an emphasis on metastasis-directed …

Treatment of pancreatic cancer that cannot be surgically resected currently relies on minimally
beneficial cytotoxic chemotherapy with gemcitabine. As the fourth leading cause of cancer…

Non-surgical therapies for human malignancies must negotiate complex cell signaling
pathways to impede cancer cell growth, ideally promoting death of cancer cells while sparing …

Mesenchymal stem cells (MSCs) are a multipotent cell population acquired most prominently
from bone marrow with the capacity to differentiate into osteoblasts, chondrocytes, …

Acid ceramidase (AC) overexpression has been observed in prostate cancer cell lines and
primary tumors, and contributes to resistance to chemotherapy and radiation. The …