Electrical activity in neurons requires a seamless functional coupling between plasmalemmal
ion channels and ion transporters. Although ion channels have been studied intensively …

Nociceptors and neurons in the central nervous system (CNS) that receive nociceptive input
show remarkable plasticity in response to injury. This plasticity is thought to underlie the …

Melzack and Wall's Gate Control Theory of Pain laid the theoretical groundwork for a role of
spinal inhibition in endogenous pain control. While the Gate Control Theory was based on …

Nociceptors located in the trigeminal ganglion (TG) and DRG are the primary sensors of
damaging or potentially damaging stimuli for the head and body, respectively, and are key …

The importance of the GABAergic system in spinal nociceptive processing has long been
appreciated but we have only recently begun to understand how this system is modulated by …

Nociceptors are specialized sensory neurons that detect damaging or potentially damaging
stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia. These …

Calcitonin gene-related peptide (CGRP) and/or substance P (SP) immunoreactivity as well
as isolectin B 4 (IB 4 ) binding are commonly used to define peptidergic and non-peptidergic …

2. Methods We performed RNA-seq for hDRG and integratively analyzed the transcriptome
by comparing it with publicly available human and mouse RNA-seq data sets (sources …

A rat population with variable responses to nerve injury indicated that activation of descending
inhibition with a spinal noradrenergic component prevents development of neuropathic …

Neuropathic pain encompasses a diverse array of clinical entities affecting 7–10% of the
population, which is challenging to adequately treat. Several promising therapeutics derived …