User profiles for Terence R. S. Ozolinš
 | Terence RS OzolinšProfessor Biomedical and Molecular Sciences, Queen's University Verified email at queensu.ca Cited by 458 |
[HTML][HTML] Investigation of SAMD1 ablation in mice
B Campbell, LM Weber, SJ Engle, TRS Ozolinš… - Scientific Reports, 2023 - nature.com
SAM domain-containing protein 1 (SAMD1) has been implicated in atherosclerosis, as well
as in chromatin and transcriptional regulation, suggesting a versatile and complex biological …
as in chromatin and transcriptional regulation, suggesting a versatile and complex biological …
Oxidative stress regulates the expression and activity of transcription factor activator protein-1 in rat conceptus
TRS Ozolinš, BF Hales - Journal of Pharmacology and Experimental …, 1997 - ASPET
The transcription factor activator protein-1 (AP-1), composed of the Fos and Jun families of
proto-oncogenes, is induced in response to extracellular signals as part of an immediate-…
proto-oncogenes, is induced in response to extracellular signals as part of an immediate-…
[HTML][HTML] Moderate exercise attenuates lipopolysaccharide-induced inflammation and associated maternal and fetal morbidities in pregnant rats
Fetal growth restriction (FGR) and coagulopathies are often associated with aberrant maternal
inflammation. Moderate-intensity exercise during pregnancy has been shown to increase …
inflammation. Moderate-intensity exercise during pregnancy has been shown to increase …
Refinement of a morphological scoring system for postimplantation rabbit conceptuses
…, VA Marshall, TRS Ozolinš - … Research Part B …, 2007 - Wiley Online Library
BACKGROUND: The rabbit is used extensively in developmental toxicity testing, yet basic
information on rabbit embryo development is lacking. The goals of this study were to refine a …
information on rabbit embryo development is lacking. The goals of this study were to refine a …
Rat embryos express transcripts for cyclooxygenase‐1 and carbonic anhydrase‐4, but not for cyclooxygenase‐2, during organogenesis
RD Streck, SW Kumpf, TRS Ozolinš… - … Research Part B …, 2003 - Wiley Online Library
BACKGROUND: Acetylsalicylic acid (ASA) is a rat teratogen, and exposures on gestational
days (GDs) 9 and 10 induce diaphragm, cardiac, and midline defects. ASA inhibits members …
days (GDs) 9 and 10 induce diaphragm, cardiac, and midline defects. ASA inhibits members …
[HTML][HTML] Tacrolimus in the prevention of adverse pregnancy outcomes and diabetes-associated embryopathies in obese and diabetic mice
…, MA Hewitt, SM Putos, M Wells, TRS Ozolinš… - Journal of Translational …, 2017 - Springer
Background T2DM is a high-risk pregnancy with adverse fetal and maternal outcomes
including repeated miscarriages and fetal malformations. Despite the established association …
including repeated miscarriages and fetal malformations. Despite the established association …
Defects in embryonic development of EGLN1/PHD2 knockdown transgenic mice are associated with induction of Igfbp in the placenta
TRS Ozolinš, TS Fisher, DM Nadeau, JL Stock… - Biochemical and …, 2009 - Elsevier
The HIF (hypoxia inducible factor) hydroxylases EGNL1/PHD2 has been implicated in
embryonic development. Here we knocked down EGNL1 in vivo by injecting one-cell murine …
embryonic development. Here we knocked down EGNL1 in vivo by injecting one-cell murine …
Cyclophosphamide and the Teratology Society: an awkward marriage
TRS Ozolins - Birth Defects Research Part B: Developmental …, 2010 - Wiley Online Library
Cyclophosphamide (CPA) is a potent and highly effective chemotherapeutic and
immunosuppressive agent that has been marketed for about 50 years. Reports of its teratogenicity …
immunosuppressive agent that has been marketed for about 50 years. Reports of its teratogenicity …
Thoracic skeletal defects and cardiac malformations: a common epigenetic link?
AD Weston, TRS Ozolinš… - Birth Defects Research …, 2006 - Wiley Online Library
Congenital heart defects (CHDs) are the most common birth defects in humans. In addition,
cardiac malformations represent the most frequently identified anomaly in teratogenicity …
cardiac malformations represent the most frequently identified anomaly in teratogenicity …
In vitro murine embryotoxicity of cyclophosphamide in embryos co-cultured with maternal hepatocytes: development and application of a murine embryo-hepatocyte …
TRS Ozolins, LA Oglesby, MJ Wiley, PG Wells - Toxicology, 1995 - Elsevier
The technique of whole embryo culture provides a sensitive model to evaluate both the effects,
and their underlying mechanisms, of drugs and environmental chemicals on embryonic …
and their underlying mechanisms, of drugs and environmental chemicals on embryonic …