Pharmacological characterization of FR194921, a new potent, selective, and orally active antagonist for central adenosine A1 receptors
T Maemoto, M Tada, T Mihara, N Ueyama… - Journal of …, 2004 - jstage.jst.go.jp
Adenosine A1 receptors in the brain are believed to play an important role in brain
functioning. We have discovered a novel adenosine A1 receptor antagonist, FR194921 (2-(1-methyl-4…
functioning. We have discovered a novel adenosine A1 receptor antagonist, FR194921 (2-(1-methyl-4…
Species differences in brain adenosine A1 receptor pharmacology revealed by use of xanthine and pyrazolopyridine based antagonists
T Maemoto, K Finlayson, HJ Olverman… - British journal of …, 1997 - Wiley Online Library
1 The pharmacological profile of adenosine A 1 receptors in human, guinea‐pig, rat and
mouse brain membranes was characterized in a radioligand binding assay by use of the …
mouse brain membranes was characterized in a radioligand binding assay by use of the …
Pharmacological Characterization of a Simple Behavioral Response Mediated Selectively by Central Adenosine A1 Receptors, Using In Vivo and In VitroTechniques
HM Marston, K Finlayson, T Maemoto… - … of Pharmacology and …, 1998 - ASPET
The behavioral profile of a range of adenosine receptor ligands was examined in rats using
a locomotor activity model. Adenosine receptor agonists, including the selective A 1 receptor …
a locomotor activity model. Adenosine receptor agonists, including the selective A 1 receptor …
Neuroprotective efficacy of FR901459, a novel derivative of cyclosporin A, in in vitro mitochondrial damage and in vivo transient cerebral ischemia models
…, Y Furuichi, N Tojo, A Moriguchi, T Maemoto… - Brain research, 2007 - Elsevier
The immunosuppressant cyclosporin A (CsA) has been shown to exert potent neuroprotective
effects, possibly via the inhibition of calcineurin and mitochondrial permeability transition …
effects, possibly via the inhibition of calcineurin and mitochondrial permeability transition …
A novel potent radical scavenger, 8-(4-fluorophenyl)-2-((2E)-3-phenyl-2-propenoyl)-1, 2, 3, 4-tetrahydropyrazolo [5, 1-c][1, 2, 4] triazine (FR210575), prevents …
A Iwashita, T Maemoto, H Nakada, I Shima… - … of Pharmacology and …, 2003 - ASPET
Reactive oxygen species (ROS) play a vital role in brain damage after cerebral ischemia-reperfusion
injury, and ROS scavengers have been shown to exert neuroprotective effects …
injury, and ROS scavengers have been shown to exert neuroprotective effects …
Novel neuroprotective compound SCH-20148 rescues thymocytes and SH-SY5Y cells from thapsigargin-induced mitochondrial membrane potential reduction and …
Y Muramatsu, T Maemoto, A Iwashita… - European journal of …, 2007 - Elsevier
Mitochondrial membrane potential plays an important role in cell survival. Transitions in
mitochondrial permeability, which indicate the imminent destruction of the organelles, have been …
mitochondrial permeability, which indicate the imminent destruction of the organelles, have been …
Pyrazolopyridine derivatives act as competitive antagonists of brain adenosine A1 receptors:[35S] GTPγS binding studies
H Ito, T Maemoto, A Akahane, SP Butcher… - European journal of …, 1999 - Elsevier
The effects of adenosine receptor ligands and three novel pyrazolopyridine derivatives on
guanosine-5′-O-(3-[ 35 S ]thio)triphosphate ([ 35 S ]GTPγS) binding to rat cerebral cortical …
guanosine-5′-O-(3-[ 35 S ]thio)triphosphate ([ 35 S ]GTPγS) binding to rat cerebral cortical …
[PDF][PDF] Comparison of effects of MgCl~ 2 and Gpp (NH) p on antagonist and agonist radioligand binding to adenosine A~ 1 receptors
K Finlayson, T Maemoto, SP Butcher, J Sharkey… - Acta Pharmacologica …, 2003 - Citeseer
AIM: To investigate modulation of antagonist and agonist binding to adenosine A1 receptors
by MgCl2 and 5-guanylimidodiphosphate (Gpp (NH) p) using rat brain membranes and the …
by MgCl2 and 5-guanylimidodiphosphate (Gpp (NH) p) using rat brain membranes and the …
[PDF][PDF] A Novel Potent Radical Scavenger, FR210575, Prevents Neuronal Cell Death in Cultured Primary Neurons and Attenuates Brain Injury Following Ischemia in …
A Iwashita, T Maemoto, H Nakada, I Shima… - … of Pharmacology and …, 2003 - Citeseer
Reactive oxygen species (ROS) play a vital role in brain damage following cerebral
ischemia-reperfusion injury, and ROS scavengers have been shown to exert neuroprotective effects …
ischemia-reperfusion injury, and ROS scavengers have been shown to exert neuroprotective effects …
Discontinuation of infliximab in patients with ulcerative colitis in remission (HAYABUSA): a multicentre, open-label, randomised controlled trial
…, M Watanabe, T Hibi, S Kato, A Maemoto… - The Lancet …, 2021 - thelancet.com
Background Anti-tumour necrosis factor (TNF) agents are the mainstay of long-term treatment
for refractory ulcerative colitis. However, long-term use of anti-TNF therapy might lead to an …
for refractory ulcerative colitis. However, long-term use of anti-TNF therapy might lead to an …