BAP31 regulates mitochondrial function via interaction with Tom40 within ER-mitochondria contact sites
T Namba - Science advances, 2019 - science.org
The endoplasmic reticulum (ER) is composed of large membrane-bound compartments,
and its membrane subdomain appears to be in close contact with mitochondria via ER-…
and its membrane subdomain appears to be in close contact with mitochondria via ER-…
Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice
T Hoshino, N Murao, T Namba, M Takehara… - Journal of …, 2011 - Soc Neuroscience
Amyloid-β peptide (Aβ) plays an important role in the pathogenesis of Alzheimer's disease (AD).
Aβ is generated by proteolysis of β-amyloid precursor protein (APP) and is cleared by …
Aβ is generated by proteolysis of β-amyloid precursor protein (APP) and is cleared by …
[HTML][HTML] Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis
KI Tanaka, T Namba, Y Arai, M Fujimoto… - Journal of Biological …, 2007 - ASBMB
Inflammatory bowel disease (IBD) involves infiltration of leukocytes into intestinal tissue,
resulting in intestinal damage induced by reactive oxygen species (ROS). Pro-inflammatory …
resulting in intestinal damage induced by reactive oxygen species (ROS). Pro-inflammatory …
Positive role of CCAAT/enhancer-binding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development …
T Namba, KI Tanaka, Y Ito, T Ishihara, T Hoshino… - The American journal of …, 2009 - Elsevier
Although recent reports suggest that the endoplasmic reticulum (ER) stress response is
induced in association with the development of inflammatory bowel disease, its role in the …
induced in association with the development of inflammatory bowel disease, its role in the …
Therapeutic effect of lecithinized superoxide dismutase against colitis
T Ishihara, KI Tanaka, Y Tasaka, T Namba… - … of Pharmacology and …, 2009 - ASPET
Ulcerative colitis (UC) involves intestinal mucosal damage induced by reactive oxygen
species (ROS), in particular, superoxide anion. Superoxide dismutase (SOD) catalyzes …
species (ROS), in particular, superoxide anion. Superoxide dismutase (SOD) catalyzes …
[PDF][PDF] CDIP1-BAP31 complex transduces apoptotic signals from endoplasmic reticulum to mitochondria under endoplasmic reticulum stress
T Namba, F Tian, K Chu, SY Hwang, KW Yoon, S Byun… - Cell reports, 2013 - cell.com
Resolved endoplasmic reticulum (ER) stress response is essential for intracellular
homeostatic balance, but unsettled ER stress can lead to apoptosis. Here, we show that a …
homeostatic balance, but unsettled ER stress can lead to apoptosis. Here, we show that a …
Heat shock protein 70 protects against bleomycin-induced pulmonary fibrosis in mice
KI Tanaka, Y Tanaka, T Namba, A Azuma… - Biochemical …, 2010 - Elsevier
Idiopathic pulmonary fibrosis (IPF) involves infiltration of leucocytes, pulmonary injury,
fibrosis and resulting pulmonary dysfunction. Myofibroblasts and transforming growth factor (TGF)-…
fibrosis and resulting pulmonary dysfunction. Myofibroblasts and transforming growth factor (TGF)-…
[HTML][HTML] A role for HSP70 in protecting against indomethacin-induced gastric lesions
S Suemasu, KI Tanaka, T Namba, T Ishihara… - Journal of biological …, 2009 - ASBMB
A major clinical problem encountered with the use of nonsteroidal anti-inflammatory drugs (NSAIDs),
such as indomethacin, is gastrointestinal complications. Both NSAID-dependent …
such as indomethacin, is gastrointestinal complications. Both NSAID-dependent …
[PDF][PDF] Small-molecule reactivation of mutant p53 to wild-type-like p53 through the p53-Hsp40 regulatory axis
TP53 is the most frequently mutated gene in human cancer, and small-molecule reactivation
of mutant p53 function represents an important anticancer strategy. A cell-based, high-…
of mutant p53 function represents an important anticancer strategy. A cell-based, high-…
[HTML][HTML] Involvement of intracellular Ca2+ levels in nonsteroidal anti-inflammatory drug-induced apoptosis
…, W Tomisato, T Hoshino, T Ishihara, T Namba… - Journal of Biological …, 2005 - ASBMB
We recently reported that nonsteroidal anti-inflammatory drug (NSAID)-induced gastric
lesions involve NSAID-induced apoptosis of gastric mucosal cells, which in turn involves the …
lesions involve NSAID-induced apoptosis of gastric mucosal cells, which in turn involves the …