The endoplasmic reticulum (ER) is composed of large membrane-bound compartments,
and its membrane subdomain appears to be in close contact with mitochondria via ER-…

Amyloid-β peptide (Aβ) plays an important role in the pathogenesis of Alzheimer's disease (AD).
Aβ is generated by proteolysis of β-amyloid precursor protein (APP) and is cleared by …

Inflammatory bowel disease (IBD) involves infiltration of leukocytes into intestinal tissue,
resulting in intestinal damage induced by reactive oxygen species (ROS). Pro-inflammatory …

Although recent reports suggest that the endoplasmic reticulum (ER) stress response is
induced in association with the development of inflammatory bowel disease, its role in the …

Ulcerative colitis (UC) involves intestinal mucosal damage induced by reactive oxygen
species (ROS), in particular, superoxide anion. Superoxide dismutase (SOD) catalyzes …

Resolved endoplasmic reticulum (ER) stress response is essential for intracellular
homeostatic balance, but unsettled ER stress can lead to apoptosis. Here, we show that a …

Idiopathic pulmonary fibrosis (IPF) involves infiltration of leucocytes, pulmonary injury,
fibrosis and resulting pulmonary dysfunction. Myofibroblasts and transforming growth factor (TGF)-…

A major clinical problem encountered with the use of nonsteroidal anti-inflammatory drugs (NSAIDs),
such as indomethacin, is gastrointestinal complications. Both NSAID-dependent …

TP53 is the most frequently mutated gene in human cancer, and small-molecule reactivation
of mutant p53 function represents an important anticancer strategy. A cell-based, high-…

We recently reported that nonsteroidal anti-inflammatory drug (NSAID)-induced gastric
lesions involve NSAID-induced apoptosis of gastric mucosal cells, which in turn involves the …