Toll-like receptors (TLRs) and complement are 2 components of innate immunity that are
critical for first-line host defense and elicitation of adaptive immune responses. Many pathogen-…

Background— Microvascular renal and retinal diseases are common major complications of
type 2 diabetes mellitus. The relation between plasma lipids and microvascular disease is …

,3-Dichlorophenyl)-1 -.Piperazinyl]Butyloxy}-3,4- Dihydro-2(1 H)-Quinolinone (OPC-1 4597),
a New Putative Antipsychotic Drug wit Page 1 Vol. 274. No. 1 Printed in USA …

Decay-accelerating factor ([DAF] CD55) is a glycosylphosphatidylinositol-anchored membrane
inhibitor of complement with broad clinical relevance. Here, we establish an additional …

Both inflammatory diseases and cancer are associated with heightened protein translation.
However, the mechanisms of translational regulation and the roles of translation factors in …

Renal ischemia-reperfusion injury (IRI) is a feature of ischemic acute renal failure and it
impacts both short-and long-term graft survival after kidney transplantation. Complement …

The complement system plays an important role in host defense. However, if not properly
regulated, activated complement can also cause significant damage to host tissues. To prevent …

Department of Diabetes, Endocrinology and Metabolism, Tokyo Medical University, Tokyo
160-0023, Japan abstract. We prospectively examined the additional effects of highly purified …

Toll-like receptors (TLRs) and complement are 2 major components of innate immunity that
provide a first-line host defense and shape the adaptive immune responses. We show here …

Properdin is a positive regulator of alternative pathway (AP) complement. The current
understanding of properdin function is that it facilitates AP complement activation by stabilizing the …