A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

T Yokomizo, T Izumi, K Chang, Y Takuwa, T Shimizu - Nature, 1997 - nature.com
Leukotriene B 4 (LTB 4 ) 1 is a potent chemoattractant that is primarily involved in inflammation,
immune responses and host defence against infection 2 . LTB 4 activates inflammatory …

A Second Leukotriene B4 Receptor, Blt2: A New Therapeutic Target in Inflammation and Immunological Disorders

T Yokomizo, K Kato, K Terawaki, T Izumi… - The Journal of …, 2000 - rupress.org
Leukotriene B 4 (LTB 4 ) is a potent chemoattractant and activator of both granulocytes and
macrophages. The actions of LTB 4 appear to be mediated by a specific G protein–coupled …

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery

LZ Benet, T Izumi, Y Zhang, JA Silverman… - Journal of controlled …, 1999 - Elsevier
Cytochrome P-450 3A4 (CYP3A4), the major phase I drug metabolizing enzyme in humans,
and the multidrug efflux pump, MDR or P-glycoprotein (P-gp), are present at high levels in …

Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2

T Nagase, N Uozumi, S Ishii, K Kume, T Izumi… - Nature …, 2000 - nature.com
Adult respiratory distress syndrome (ARDS) is characterized by acute lung injury with a high
mortality rate and yet its mechanism is poorly understood. Sepsis syndrome and acid …

Leukotriene B4: metabolism and signal transduction

T Yokomizo, T Izumi, T Shimizu - Archives of biochemistry and biophysics, 2001 - Elsevier
Leukotriene B 4 (LTB 4 ) is known as one of the most potent chemoattractants and activators
of leukocytes and is involved in inflammatory diseases. Enzymes involved in the …

[HTML][HTML] Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2

T Yokomizo, K Kato, H Hagiya, T Izumi… - Journal of Biological …, 2001 - ASBMB
Leukotriene B 4 , an arachidonate metabolite, is a potent chemoattractant of leukocytes
involved in various inflammatory diseases. Two G-protein-coupled receptors for leukotriene B 4 …

[HTML][HTML] Cystathionine γ-lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury

…, N Akahoshi, H Yamada, S Nakano, T Izumi… - Journal of Biological …, 2010 - ASBMB
Cysteine is considered a nonessential amino acid in mammals as it is synthesized from
methionine via trans-sulfuration. However, premature infants or patients with hepatic failure may …

A study to survey susceptible genetic factors responsible for troglitazone‐associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus

…, K Miyoshi, K Nakamura, T Izumi… - Clinical …, 2003 - Wiley Online Library
Background and objective Troglitazone is a 2,4‐thiazolidinedione antidiabetic agent with
insulin‐sensitizing activities. This agent had been used efficiently in a large number of patients …

[HTML][HTML] Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A

…, T Hattori, S Nakane, K Tatei, T Izumi - Journal of Biological …, 2005 - ASBMB
G2A is a G protein-coupled receptor that is predominantly expressed in lymphoid tissues and
macrophages. G2A can be induced by diverse stimuli to cause cell cycle arrest in the G 2 /…

Alpha-adrenergic activity and urethral pressure in prostatic zone in benign prostatic hypertrophy

…, Y Kumamoto, E Yokoyama, T Tsukamoto, T Izumi… - The Journal of …, 1982 - Elsevier
In order to examine to what extent adrenergic mechanism contributes to the urethral pressure
in patients with benign prostatic hypertrophy, changes in the intraurethral pressure in the …