Recent compelling evidence has lead to renewed interest in the role of antibodies and
immune complexes in the pathogenesis of several autoimmune disorders, such as rheumatoid …

In a yeast two‐hybrid screen we identified a member of the 14‐3‐3 family of proteins that
can bind to Bcr. 14‐3‐3 beta binds to the serine/threonine rich region B in the kinase domain …

Most mammalian cells neither express any Gal4-like activity nor endogenous estrogen
receptor, thus rendering estrogen an inert signal for them. For these two reasons we have …

Constitutive expression of c-Fos, FosB, Fra-1, or c-Jun in rat fibroblasts leads to up-regulation
of the immediate-early gene fra-1. Using the posttranslational FosER induction system, we …

BACKGROUND: Activation of the IgE receptor, FcɛRI, in mast cells is the key mechanism
initiating and propagating pathophysiological responses in allergic rhinitis. OBJECTIVE: …

JAK3, a member of the Janus kinase family, is predominantly expressed in hemopoietic
cells and binds specifically to the common γ chain of a subfamily of cytokine receptors that …

Recently, we have reported the purification and cloning of a novel G protein βγ subunit-activated
phosphoinositide 3-kinase from pig neutrophils. The enzyme comprises a p110γ …

Dimethyl fumarate 1 is approved for the treatment of multiple sclerosis but is also associated
with off-target activation of the niacin receptor. By using a tetrazolone or triazolone …

c-Fos is a major component of the transcription factor AP-1 which has been implicated in the
control of cell proliferation and differentiation as well as in transformation. In order to identify …

The history of US women scientists’ organizations from the 19th century until the 1960s reflects
both women’s relative powerlessness within the science community and their reluctance …