The clinical use of first-generation phosphoinositide 3-kinase (PI3K)δ inhibitors in B-cell
malignancies is hampered by hepatotoxicity, requiring dose reduction, treatment interruption, …

Phosphatidylinositol 3-kinases (PI3Ks) belong to a family of lipid signaling kinases that
phosphorylate phosphatidylinositol-4,5-bisphosphate (PIP2), giving rise to phosphatidylinositol-3,…

Immune checkpoint blockade has shown impressive efficacy in patients with inflamed tumors,
although minimal activity has been observed in tumors lacking T cells. Myeloid cells are …

The PIM family of serine-threonine protein kinases (PIM1, PIM2 and PIM3) was initially
identified as preferential integration sites of the Moloney murine leukemia virus in Eμ-myc mice, …

An adult female Syrian hamster (Mesocricetus auratus) presented with a large, ulcerated
lesion in its right cheek pouch; this wound interfered with the animal's ability to masticate. As a …

The clinical use of first-generation phosphoinositide 3-kinase (PI3K)δ inhibitors in B-cell
malignancies is hampered by hepatotoxicity, requiring dose reduction, treatment interruption, …

Bromodomain and Extra Terminal (BET) protein inhibitors have emerged as a potentially
effective therapeutic option for multiple tumor types, through their ability to regulate expression …

The PIM family of serine-threonine protein kinases (PIM1, PIM2 and PIM3) mediates responses
to cytokines and growth factors and drives cell proliferation and survival in a number of …

Multiple myeloma (MM) is a disease of plasma cell transformation. Current therapy for MM is
initially effective, but nearly all tumors relapse, making new therapeutic options a necessity. …

Sickle cell disease (SCD) is an autosomal recessive genetic disorder caused by a point
mutation in the human β-globin gene. Patients harboring this mutation can exhibit long-chain …