Major features of the transcellular signaling mechanism responsible for endothelium-dependent
regulation of vascular smooth muscle tone are unresolved. We identified local calcium (…

Alzheimer’s disease is the fourth largest cause of death for people over 65 years of age.
Dementia of Alzheimer’s type is the commonest form of dementia, the other two forms being …

The measurement of vascular function in isolated vessels has revealed important insights
into the structural, functional, and biomechanical features of the normal and diseased …

Endothelial cell dysfunction, characterized by a diminished response to endothelial cell–dependent
vasodilators, is a hallmark of hypertension. TRPV4 channels play a major role in …

Memory impairment induced by intracerebroventricular (ICV) injection of streptozotocin (STZ)
in rats is associated with impaired brain glucose and energy metabolism, oxidative stress …

Long-lasting Ca 2+ (Ca L ) channels of the Ca v 1.2 gene family are heteromultimeric structures
that are minimally composed of a pore-forming α 1C subunit and regulatory β and α 2 δ …

Intracerebroventricular (ICV) injection of streptozotocin (STZ) causes cognitive impairment
in rats. ICV STZ is known to impair cholinergic neurotransmission by decreasing choline …

Key points Increase in endothelial cell (EC) calcium activates calcium‐sensitive intermediate
and small conductance potassium (IK and SK) channels, thereby causing hyperpolarization …

Recent studies have focused on the contribution of capillary endothelial TRPV4 channels to
pulmonary pathologies, including lung edema and lung injury. However, in pulmonary …

Endothelial cells and smooth muscle cells of resistance arteries mediate opposing responses
to mechanical forces acting on the vasculature, promoting dilation in response to flow and …