Nicotinic ACh (nACh) receptors in the CNS are composed of a diverse array of subunits and
have a range of pharmacological properties. However, despite the fact that they are ligand-…

Neuronal nicotinic acetylcholine (nACh) receptors in the brain are more commonly associated
with modulatory events than mediation of synaptic transmission. nACh receptors have a …

Nicotinic acetylcholine receptors (nACh receptors2) in jawed vertebrates are prototypical
members of the multisubunit, neurotransmitter-gated superfamily of ion channels (ionotropic …

Chronic exposure to agonist (or conditions that increase the synaptic concentration of the
natural transmitter, such as blockade of inactivation mechanisms) results in a downregulation …

This study establishes that presynaptic nicotinic receptors modulate dopamine release in the
mouse striatum. Nicotinic agonists elicit a dose‐dependent increase in the release of [ 3 H]…

α7 neuronal nicotinic acetylcholine receptors (nAChRs) constitute one of the predominant
nAChR subtypes in the mammalian brain. Within the ventral tegmental area (VTA), nicotine …

The addictive potential of nicotine is clearly recognized by the tenacity of tobacco smoking
for most users, and has prompted extensive psychopharmacological studies in animals. In …

6-Hydroxydopamine is a neurotoxin commonly used to lesion dopaminergic pathways and
generate experimental models for Parkinson disease, however, the cellular mechanism of 6-…

Methyllycaconitine (MLA), a norditerpenoid alkaloid isolated from Delphinium seeds, is one
of the most potent non-proteinacious ligands that is selective for αbungarotoxin-sensitive …

The modulation of dopamine release by presynaptic nicotinic receptors in vitro is well established,
but the significance of this effect in vivo is unclear. We have characterised the effect of …