Background—Determinants of left atrial (LA) reservoir function and its influence on left
ventricular (LV) function have not been quantified. Methods and Results—In an open-pericardium, …

BACKGROUND: Blood for transfusion is stored for up to 42 days. Older blood develops lesions
and accumulates potentially injurious substances. Some studies report increasing toxicity …

During intravascular hemolysis in human disease, vasomotor tone and organ perfusion may
be impaired by the increased reactivity of cell-free plasma hemoglobin (Hb) with NO. We …

Two-year-old purpose-bred beagles (n = 24) infected with Staphylococcus aureus pneumonia
were randomized in a blinded fashion for exchange transfusion with either 7- or 42-day-…

Introduction The purpose of this study was to identify risk factors associated with local tumor
progression-free survival (LTPFS) and complications after colorectal liver metastases (CLM) …

The success of a small animal model to study critical illness is, in part, dependent on the
ability of the model to simulate the human condition. Intra-tracheal inoculation of a known …

In a randomized controlled blinded trial, 2-year-old purpose-bred beagles (n = 24), with
Staphylococcus aureus pneumonia, were exchanged-transfused with either 7- or 42-day-old …

During the last half-century, numerous antiinflammatory agents were tested in dozens of
clinical trials and have proven ineffective for treating septic shock. The observation in multiple …

Cryoablation of a solitary tumor mass releases intact tumor antigens and can induce
protective antitumor immunity but has limited efficacy in the treatment of established metastatic …

Background In experimental pneumonia we found that transfused older blood increased
mortality and lung injury that was associated with increased in vivo hemolysis and elevated …