The vanilloid receptor-1 (VR1) is a ligand-gated, non-selective cation channel expressed
predominantly by sensory neurons. VR1 responds to noxious stimuli including capsaicin, the …

The Xist gene has been proposed as a candidate for the X inactivation centre, the master
regulatory switch locus that controls X chromosome inactivation. So far this hypothesis has …

Metformin is among the most widely prescribed drugs for the treatment of type 2 diabetes.
Organic cation transporter 1 (OCT1) plays a role in the hepatic uptake of metformin, but its role …

The transient receptor potential (TRP) vanilloid 4 (TRPV4) member of the TRP superfamily
has recently been implicated in numerous physiological processes. In this study, we describe …

The onset of X inactivation is preceded by a marked increase in the level of Xist RNA. Here
we demonstrate that increased stability of Xist RNA is the primary determinant of …

The mouse Xist gene is expressed exclusively from the inactive X chromosome and may
control the initiation of X tnactivatlon. We show that in somatic tissues the 5’end of the silent XIsf …

The Grb10 adapter protein is capable of interacting with a variety of receptor tyrosine kinases,
including, notably, the insulin receptor. Biochemical and cell culture experiments have …

Transforming growth factor (TGF)-β plays a critical role in diabetic nephropathy. To isolate the
contribution of one of the signaling pathways of TGF-β, the Smad3 gene in the mouse was …

Developmental regulation of the mouse Xist gene at the onset of X chromosome inactivation
is mediated by RNA stabilization. Here, we show that alternate promoter usage gives rise to …

The purinergic receptor P2X 7 is expressed on immune cells, and its stimulation results in
the release of IL-1β from macrophages. Its absence, as evidenced from the analysis of two …