ABCA1, the ATP-binding cassette protein mutated in Tangier disease, mediates the efflux of
excess cellular sterol to apoA-I and thereby the formation of high density lipoprotein. The …

We have previously established that the ABCA1 transporter, which plays a critical role in the
lipidation of extracellular apolipoprotein acceptors, traffics between late endocytic vesicles …

Interleukin‐1β ( IL ‐1β), a potent pro‐inflammatory cytokine, has been implicated in many
diseases, including atherosclerosis. Activation of IL ‐1β is controlled by a multi‐protein complex…

Human familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) is characterized
by low HDL, accumulation of an abnormal cholesterol-rich multilamellar particle called …

Cholesterol esterification within plasma lipoprotein particles is catalyzed by lecithin:cholesterol
acyltransferase (LCAT). The impact of the overexpression of this enzyme on plasma …

The role of endothelial ABCA1 expression in reverse cholesterol transport (RCT) was
examined in transgenic mice, using the endothelial-specific Tie2 promoter. Human ABCA1 (…

The polyene antibiotic filipin, which forms specific complexes with 3β‐hydroxysterols, displays
spectral properties compatible with its use in flow microfluorometry (FMF). The purpose of …

Lecithin:cholesterol acyltransferase (LCAT) catalyzes plasma cholesteryl ester formation and
is defective in familial lecithin:cholesterol acyltransferase deficiency (FLD), an autosomal …

Background: A small number of immunoassays on several different types of analyzers were
recently adversely affected by tube additives in Becton Dickinson (BD) Vacutainer® SST™, …

Elevated low density lipoprotein cholesterol (LDL-C) and reduced high density lipoprotein
cholesterol (HDL-C) concentrations are independent risk factors for coronary heart disease. …