[PDF][PDF] The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis

S Fiorucci, E Antonelli, A Mencarelli, S Orlandi… - …, 2005 - Wiley Online Library
The regulation of sinusoidal resistance is dependent on the contraction of hepatic stellate
cells (HSC) around sinusoidal endothelial cell (SEC) through paracrine cross‐talk of …

Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs

…, E Distrutti, G Rizzo, A Mencarelli, S Orlandi… - Gastroenterology, 2005 - Elsevier
Background & Aims: Hydrogen sulfide (H 2 S), an endogenous gaseous mediator that causes
vasodilation, is generated in mammalian tissues by cystathionine β-synthase (CBS) and …

The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

…, G Rizzo, B Renga, A Mencarelli, L Riccardi, S Orlandi… - Gastroenterology, 2004 - Elsevier
Background & Aims: The farnesoid X receptor (FXR) is an endogenous sensor for bile acids
and inhibits bile acid synthesis by inducing small heterodimer partner (SHP) gene …

Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels

…, L Sediari, A Mencarelli, B Renga, S Orlandi… - … of Pharmacology and …, 2006 - ASPET
Hydrogen sulfide (H 2 S) functions as a neuromodulator, but whether it modulates visceral
perception and pain is unknown. Cystathionineβ -synthase (CBS) and cystathionine-γ-lyase (…

Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis

S Fiorucci, C Clerici, E Antonelli, S Orlandi… - … of Pharmacology and …, 2005 - ASPET
The farnesoid X receptor (FXR), an endogenous sensor for bile acids, regulates a program
of genes involved in bile acid biosynthesis, conjugation, and transport. Cholestatic liver …

A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic …

…, B Renga, A Mencarelli, L Riccardi, S Orlandi… - … of Pharmacology and …, 2005 - ASPET
The farnesoid X receptor (FXR) is expressed by and regulates hepatic stellate cells (HSCs).
In the present study, we investigated whether 6-ethyl chenodeoxycholic acid (6-ECDCA or …

Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist

…, G Ciaccioli, L Donadio, G Rizzo, S Orlandi… - Molecular …, 2010 - ASPET
Two dedicated receptors for bile acids (BAs) have been identified, the nuclear hormone
receptor farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5, which represent …

5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1, 2] dithiol-3yl)-phenyl ester (ATB-429), a hydrogen sulfide-releasing derivative of mesalamine, exerts antinociceptive …

…, L Sediari, A Mencarelli, B Renga, S Orlandi… - … of Pharmacology and …, 2006 - ASPET
H 2 S functions as a neuromodulator and exerts anti-inflammatory activities. Recent data
indicate that irritable bowel syndrome (IBS) is linked to inflammation of the gastrointestinal tract. …

[HTML][HTML] Pasta naturally enriched with isoflavone aglycons from soy germ reduces serum lipids and improves markers of cardiovascular risk

…, D Castellani, E Nardi, G Sabatino, S Orlandi… - The Journal of …, 2007 - Elsevier
Most studies of soy and cholesterol have tested foods made from purified soy proteins
containing mainly isoflavone glycosides. Fermented soy foods have mainly isoflavone aglycons …

Environmental and land use determinants of grassland patch diversity in the western and eastern Alps under agro-pastoral abandonment

S Orlandi, M Probo, T Sitzia, G Trentanovi… - Biodiversity and …, 2016 - Springer
Agro-pastoral decline in European mountain areas has recently caused changes to traditional
landscapes with negative consequences on semi-natural grassland conservation and the …