Cellular actions of topiramate: blockade of kainate‐evoked inward currents in cultured hippocampal neurons

JW Gibbs III, S Sombati, RJ DeLorenzo, DA Coulter - Epilepsia, 2000 - Wiley Online Library
Purpose: This study was undertaken to evaluate the effects of topiramate (TPM) on excitatory
amino acid‐evoked currents. Methods:Kainate and N‐methyl‐d‐aspartate (NMDA) were …

Recurrent spontaneous seizure activity in hippocampal neuronal networks in culture

S Sombati, RJ Delorenzo - Journal of neurophysiology, 1995 - journals.physiology.org
1. Experiments were carried out using intracellular recording techniques on hippocampal
neurons maintained in culture to determine if populations of hippocampal neurons could be …

Generation of specific behaviors in a locust by local release into neuropil of the natural neuromodulator octopamine

S Sombati, G Hoyle - Journal of neurobiology, 1984 - Wiley Online Library
The natural insect neuromodulator octopamine (OCT) was released iontophoretically into
regions of neuropil in locust metathoracic ganglia. A narrowly‐defined site was found on one …

Calcium‐dependent Epileptogenesis in an In Vitro Model of Stroke‐induced “Epilepsy”

DA Sun, S Sombati, RE Blair, RJ DeLorenzo - Epilepsia, 2002 - Wiley Online Library
Purpose: Stroke is the most common cause of acquired epilepsy. The purpose of this
investigation was to characterize the role of calcium in the in vitro, glutamate injury–induced …

Glutamate injury–induced Epileptogenesis in hippocampal neurons: an in vitro model of stroke-induced “epilepsy”

DA Sun, S Sombati, RJ DeLorenzo - Stroke, 2001 - Am Heart Assoc
Background and Purpose— Stroke is the major cause of acquired epilepsy. The mechanisms
of ischemia-induced epileptogenesis are not understood, but glutamate is associated with …

An in vitro model of stroke‐induced epilepsy: elucidation of the roles of glutamate and calcium in the induction and maintenance of stroke‐induced epileptogenesis

RJ DeLorenzo, DA Sun, RE Blair, S Sombati - International review of …, 2007 - Elsevier
Stroke is a major risk factor for developing acquired epilepsy (AE). Although the underlying
mechanisms of ischemia‐induced epileptogenesis are not well understood, glutamate has …

Activation of the cannabinoid type-1 receptor mediates the anticonvulsant properties of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy …

RE Blair, LS Deshpande, S Sombati… - … of Pharmacology and …, 2006 - ASPET
Cannabinoids have been shown to have anticonvulsant properties, but no studies have
evaluated the effects of cannabinoids in the hippocampal neuronal culture models of acquired …

Traumatic brain injury causes a long‐lasting calcium (Ca2+)‐plateau of elevated intracellular Ca levels and altered Ca2+ homeostatic mechanisms in hippocampal …

DA Sun, LS Deshpande, S Sombati… - European Journal of …, 2008 - Wiley Online Library
Traumatic brain injury (TBI) survivors often suffer chronically from significant morbidity associated
with cognitive deficits, behavioral difficulties and a post‐traumatic syndrome and thus it …

Aging is associated with elevated intracellular calcium levels and altered calcium homeostatic mechanisms in hippocampal neurons

…, LS Deshpande, RE Blair, DS Carter, S Sombati… - Neuroscience …, 2007 - Elsevier
Aging is associated with increased vulnerability to neurodegenerative conditions such as
Parkinson's and Alzheimer's disease and greater neuronal deficits after stroke and epilepsy. …

Prolonged activation of the N-methyl-d-aspartate receptor–Ca2+ transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal …

…, S Pal, S Sombati - Proceedings of the …, 1998 - National Acad Sciences
The molecular basis for developing symptomatic epilepsy (epileptogenesis) remains ill
defined. We show here in a well characterized hippocampal culture model of epilepsy that the …