Involvement of BCRP (ABCG2) in the biliary excretion of pitavastatin
Pitavastatin, a novel potent 3-hydroxymethylglutaryl coenzyme A reductase inhibitor, is
distributed selectively to the liver and excreted into bile in unchanged form in rats. We reported …
distributed selectively to the liver and excreted into bile in unchanged form in rats. We reported …
Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion …
S Matsushima, K Maeda, C Kondo, M Hirano… - … of Pharmacology and …, 2005 - ASPET
Until recently, it was generally believed that the transport of various organic anions across
the bile canalicular membrane was mainly mediated by multidrug resistance-associated …
the bile canalicular membrane was mainly mediated by multidrug resistance-associated …
The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine
S Matsushima, K Maeda, K Inoue, K Ohta… - Drug metabolism and …, 2009 - ASPET
Cimetidine is known to cause drug-drug interactions (DDIs) with organic cations in the kidney,
and a previous clinical study showed that coadministration of cimetidine or probenecid …
and a previous clinical study showed that coadministration of cimetidine or probenecid …
[HTML][HTML] Efficacy and safety of omalizumab in Japanese and Korean patients with refractory chronic spontaneous urticaria
…, JH Choi, A Fukunaga, J Wang, S Matsushima… - Journal of …, 2017 - Elsevier
Background Many patients with chronic spontaneous/idiopathic urticaria (CSU/CIU) do not
respond adequately to treatment with non-sedating H1 antihistamines (H1AH). There are …
respond adequately to treatment with non-sedating H1 antihistamines (H1AH). There are …
Involvement of multiple efflux transporters in hepatic disposition of fexofenadine
S Matsushima, K Maeda, H Hayashi, Y Debori… - Molecular …, 2008 - ASPET
Fexofenadine (FEX) is mainly eliminated from the liver into bile in unchanged form. We
demonstrated previously that organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 …
demonstrated previously that organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 …
Investigation of the inhibitory effects of various drugs on the hepatic uptake of fexofenadine in humans
S Matsushima, K Maeda, N Ishiguro, T Igarashi… - Drug metabolism and …, 2008 - ASPET
Fexofenadine (FEX), an H 1 -receptor antagonist, is eliminated from the liver mainly in an
unchanged form. Our previous study suggested that organic anion-transporting polypeptide (…
unchanged form. Our previous study suggested that organic anion-transporting polypeptide (…
Establishment of a set of double transfectants coexpressing organic anion transporting polypeptide 1B3 and hepatic efflux transporters for the characterization of the …
…, K Maeda, A Saito, W Kishimoto, S Matsushima… - Drug metabolism and …, 2008 - ASPET
In the hepatic uptake of organic anions, organic anion transporting polypeptide (OATP) 1B1
is believed to be mainly involved. We have constructed a set of double-transfected cells …
is believed to be mainly involved. We have constructed a set of double-transfected cells …
Efficacy and safety of omalizumab for the treatment of refractory chronic spontaneous urticaria in Japanese patients: Subgroup analysis of the phase 3 POLARIS study
…, G Kaiser, J Wang, S Matsushima… - Allergology …, 2018 - jstage.jst.go.jp
Background: Omalizumab, a humanized anti-IgE monoclonal antibody, proved efficacious
and well tolerated in patients with chronic spontaneous urticaria (CSU) refractory to H 1 …
and well tolerated in patients with chronic spontaneous urticaria (CSU) refractory to H 1 …
Ethnic sensitivity assessment–pharmacokinetic comparability between Japanese and non-Japanese healthy subjects on selected mAbs
S Matsushima, Y Huang, H Suzuki… - Expert Opinion on …, 2015 - Taylor & Francis
Objective: Ethnic sensitivity studies (ESSs), where safety and pharmacokinetics (PK) are
assessed in Japanese subjects, are routinely conducted according to Japanese regulatory …
assessed in Japanese subjects, are routinely conducted according to Japanese regulatory …
Efficacy, safety and pharmacokinetics of indacaterol in Caucasian and Japanese patients with chronic obstructive pulmonary disease: a comparison of data from two …
M Hosoe, R Woessner, S Matsushima… - Clinical Drug …, 2011 - Springer
Background: Indacaterol is a novel, inhaled, once-daily, ultra-long-acting β 2 -adrenoceptor
agonist that has been approved in the EU for the treatment of chronic obstructive pulmonary …
agonist that has been approved in the EU for the treatment of chronic obstructive pulmonary …