User profiles for Simon Hinke
 | Simon A. Hinke, Ph.D.Principal Scientist, Janssen Pharmaceutical Companies of J&J Verified email at uw.edu Cited by 3028 |
Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1)
are gut-derived incretins that potentiate glucose clearance following nutrient ingestion. …
are gut-derived incretins that potentiate glucose clearance following nutrient ingestion. …
Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1
SA Hinke, K Kühn-Wache, T Hoffmann… - Biochemical and …, 2002 - Elsevier
There is current interest in the use of inhibitors of dipeptidyl peptidase IV (DP IV) as therapeutic
agents to normalize glycemic excursions in type 2 diabetic patients. Data indicating that …
agents to normalize glycemic excursions in type 2 diabetic patients. Data indicating that …
Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis
The incretins glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1
(GLP-1) are gut hormones that act via the enteroinsular axis to potentiate insulin secretion …
(GLP-1) are gut hormones that act via the enteroinsular axis to potentiate insulin secretion …
[HTML][HTML] Glucose suppresses superoxide generation in metabolically responsive pancreatic β cells
GA Martens, Y Cai, S Hinke, G Stangé… - Journal of biological …, 2005 - ASBMB
High rates of glucose metabolism and mitochondrial electron transport have been
associated with increased mitochondrial production of reactive oxygen species (ROS). This …
associated with increased mitochondrial production of reactive oxygen species (ROS). This …
AKAP150 Contributes to Enhanced Vascular Tone by Facilitating Large-Conductance Ca2+-Activated K+ Channel Remodeling in Hyperglycemia and Diabetes …
Rationale: Increased contractility of arterial myocytes and enhanced vascular tone during
hyperglycemia and diabetes mellitus may arise from impaired large-conductance Ca 2+ -…
hyperglycemia and diabetes mellitus may arise from impaired large-conductance Ca 2+ -…
Dipeptidyl Peptidase IV-Resistant [d-Ala2]Glucose-Dependent Insulinotropic Polypeptide (GIP) Improves Glucose Tolerance in Normal and Obese Diabetic Rats
SA Hinke, RW Gelling, RA Pederson, S Manhart… - Diabetes, 2002 - Am Diabetes Assoc
The therapeutic potential of glucose-dependent insulinotropic polypeptide (GIP) for improving
glycemic control has largely gone unstudied. A series of synthetic GIP peptides modified at …
glycemic control has largely gone unstudied. A series of synthetic GIP peptides modified at …
[HTML][HTML] Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1
Aims/hypothesis The secretory function of pancreatic beta cells is synergistically stimulated
by two signalling pathways which mediate the effects of nutrients and hormones such as …
by two signalling pathways which mediate the effects of nutrients and hormones such as …
[HTML][HTML] Dipeptidyl peptidase IV (DPIV/CD26) degradation of glucagon: characterization of glucagon degradation products and DPIV-resistant analogs
Over the past decade, numerous studies have been targeted at defining structure-activity
relationships of glucagon. Recently, we have found that glucagon 1–29 is hydrolyzed by …
relationships of glucagon. Recently, we have found that glucagon 1–29 is hydrolyzed by …
Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation
Y Cai, GA Martens, SA Hinke, H Heimberg… - Free Radical Biology …, 2007 - Elsevier
AMP-activated protein kinase influences cellular metabolism, glucose-regulated gene
expression, and insulin secretion of pancreatic beta cells. Its sustained activation by culture at low …
expression, and insulin secretion of pancreatic beta cells. Its sustained activation by culture at low …
A novel pathway for regulation of glucose‐dependent insulinotropic polypeptide receptor expression in β‐cells
Glucose‐dependent insulinotropic polypeptide (GIP) is secreted postprandially and acts in
concert with glucose to stimulate insulin secretion from the pancreas. Here, we describe a …
concert with glucose to stimulate insulin secretion from the pancreas. Here, we describe a …