Numerous studies have shown that high olive oil intake reduces blood pressure (BP). These
positive effects of olive oil have frequently been ascribed to its minor components, such as α…

Importance Colorectal surgery is associated with substantial morbidity rates and a lowered
functional capacity. Optimization of the patient’s condition in the weeks prior to surgery may …

Despite recent advances in the development of new cancer therapies, the treatment options
for glioma remain limited, and the survival rate of patients has changed little over the past …

Most drugs currently used for human therapy interact with proteins, altering their activity to
modulate the pathological cell physiology. In contrast, 2-hydroxy-9-cis-octadecenoic acid (…

A master coordinator of cell growth, mTORC1 is activated by different metabolic inputs,
particularly the metabolism of glutamine (glutaminolysis), to control a vast range of cellular …

Alzheimer's disease (AD) is a neurodegenerative pathology with relevant unmet therapeutic
needs. Both natural aging and AD have been associated with a significant decline in the …

Recent studies have shown that diets rich in monounsaturated fatty acids (MUFAs) from
olive oil, a natural source of oleic acid, have beneficial effects on blood pressure (BP) in …

α-Hydroxy-9-cis-octadecenoic acid, a synthetic fatty acid that modifies the composition and
structure of lipid membranes. 2-Hydroxyoleic acid (HOA) generated interest due to its potent, …

Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the elderly. In
the last years, abnormalities of lipid metabolism and in particular of docosahexaenoic acid (…

Minerval is an oleic acid synthetic analogue that impairs lung cancer (A549) cell proliferation
upon modulation of the plasma membrane lipid structure and subsequent regulation of …