User profiles for Sigismund Huck
 | Sigismund HuckProfessor of Neuropharmacology, Center for Brain Research, Medical University of Vienna Verified email at meduniwien.ac.at Cited by 2650 |
Tranexamic acid, a widely used antifibrinolytic agent, causes convulsions by a γ-aminobutyric acidA receptor antagonistic effect
…, MG Schlag, M Berger, R Hopf, S Huck… - … of Pharmacology and …, 2002 - ASPET
Application of 4-(aminomethyl)cyclohexanecarboxylic acid (tranexamic acid; TAMCA) to the
central nervous system (CNS) has been shown to result in hyperexcitability and convulsions. …
central nervous system (CNS) has been shown to result in hyperexcitability and convulsions. …
Disturbed neurotransmitter homeostasis in ether lipid deficiency
Plasmalogens, the most prominent ether (phospho)lipids in mammals, are structural components
of most cellular membranes. Due to their physicochemical properties and abundance …
of most cellular membranes. Due to their physicochemical properties and abundance …
The point mutation γ2F77I changes the potency and efficacy of benzodiazepine site ligands in different GABAA receptor subtypes
J Ramerstorfer, R Furtmüller, E Vogel, S Huck… - European journal of …, 2010 - Elsevier
Benzodiazepine site agonists or inverse agonists enhance or reduce γ-aminobutyric acid A (GABA
A ) receptor-mediated inhibition of neurons, respectively. Recently, it was …
A ) receptor-mediated inhibition of neurons, respectively. Recently, it was …
Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit …
…, RL Papke, JM McIntosh, S Huck… - European Journal of …, 2010 - Wiley Online Library
Nicotinic acetylcholine receptors (nAChRs) mediate fast synaptic transmission in ganglia of
the autonomic nervous system. Here, we determined the subunit composition of hetero‐…
the autonomic nervous system. Here, we determined the subunit composition of hetero‐…
PWZ-029, a compound with moderate inverse agonist functional selectivity at GABAA receptors containing α5 subunits, improves passive, but not active, avoidance …
Benzodiazepine (BZ) site ligands affect vigilance, anxiety, memory processes, muscle tone
and epileptogenic propensity through modulation of neurotransmission at GABA A receptors …
and epileptogenic propensity through modulation of neurotransmission at GABA A receptors …
[HTML][HTML] Are GABAA receptors containing α5 subunits contributing to the sedative properties of benzodiazepine site agonists?
Classical benzodiazepines (BZs) exert anxiolytic, sedative, hypnotic, muscle relaxant,
anticonvulsive, and amnesic effects through potentiation of neurotransmission at GABA A …
anticonvulsive, and amnesic effects through potentiation of neurotransmission at GABA A …
[HTML][HTML] The α5 Nicotinic Acetylcholine Receptor Subunit Differentially Modulates α4β2* and α3β4* Receptors
P Scholze, S Huck - Frontiers in Synaptic Neuroscience, 2020 - frontiersin.org
Nicotine, the principal reinforcing compound in tobacco, acts in the brain by activating
neuronal nicotinic acetylcholine receptors (nAChRs). This review summarizes our current …
neuronal nicotinic acetylcholine receptors (nAChRs). This review summarizes our current …
The glutamate analogue alpha-aminoadipic acid is taken up by astrocytes before exerting its gliotoxic effect in vitro
S Huck, F Grass, H Hortnagl - Journal of Neuroscience, 1984 - Soc Neuroscience
DL- and L-alpha-aminoadipic acid (alpha-AA) are specific gliotoxins in vitro (Huck, S., F. Grass,
and ME Hatten (1984) Neuroscience 12: 783– 796). By combining immunohistochemical …
and ME Hatten (1984) Neuroscience 12: 783– 796). By combining immunohistochemical …
[HTML][HTML] Nicotinic acetylcholine receptors modulate osteoclastogenesis
Background Our aim was to investigate the role of nicotinic acetylcholine receptors (nAChRs)
in in-vitro osteoclastogenesis and in in-vivo bone homeostasis. Methods The presence of …
in in-vitro osteoclastogenesis and in in-vivo bone homeostasis. Methods The presence of …
Alternate use of distinct intersubunit contacts controls GABAA receptor assembly and stoichiometry
…, K Fuchs, R Furtmüller, B Mayer, S Huck… - Journal of …, 2001 - Soc Neuroscience
GABA A receptors are the major inhibitory transmitter receptors in the CNS. Recombinant
GABA A receptors composed of α 1 β 3 γ 2 subunits have been demonstrated to assemble as …
GABA A receptors composed of α 1 β 3 γ 2 subunits have been demonstrated to assemble as …