[PDF][PDF] Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

S Ishibashi, MS Brown, JL Goldstein… - The Journal of …, 1993 - Am Soc Clin Investig
We employed homologous recombination in embryonic stem cells to produce mice lacking
functional LDL receptor genes. Homozygous male and female mice lacking LDL receptors (…

Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity

J Osuga, S Ishibashi, T Oka, H Yagyu… - Proceedings of the …, 2000 - National Acad Sciences
Hormone-sensitive lipase (HSL) is known to mediate the hydrolysis not only of triacylglycerol
stored in adipose tissue but also of cholesterol esters in the adrenals, ovaries, testes, and …

Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression

…, Y Najima, M Nakakuki, R Nagai, S Ishibashi… - Hepatology, 2003 - Elsevier
Leptin-deficient ob/ob mice show many characteristics of obesity, including excess peripheral
adiposity as well as severe hepatic steatosis, at least in part, due to increased hepatic …

[HTML][HTML] Triglyceride lowering with pemafibrate to reduce cardiovascular risk

…, HN Ginsberg, A Goudev, S Ishibashi… - … England Journal of …, 2022 - Mass Medical Soc
Background High triglyceride levels are associated with increased cardiovascular risk, but
whether reductions in these levels would lower the incidence of cardiovascular events is …

A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

…, TJC van Berkel, UP Steinbrecher, S Ishibashi… - Nature, 1997 - nature.com
Macrophage type-I and type-II class-A scavenger receptors (MSR-A) are implicated in the
pathological deposition of cholesterol during atherogenesis as a result of receptor-mediated …

Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice.

S Ishibashi, JL Goldstein, MS Brown… - The Journal of …, 1994 - Am Soc Clin Investig
Mice that are homozygous for a targeted disruption of the LDL receptor gene (LDLR-/- mice)
were fed a diet that contained 1.25% cholesterol, 7.5% cocoa butter, 7.5% casein, and 0.5% …

[HTML][HTML] Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

…, K Ohashi, K Harada, T Gotoda, S Ishibashi… - Journal of Biological …, 1999 - ASBMB
To elucidate the physiological role of sterol regulatory element-binding protein-1 (SREBP-1),
the hepatic mRNA levels of genes encoding various lipogenic enzymes were estimated in …

High cholesterol level is essential for myelin membrane growth

…, R Tozawa, MC Wehr, F Wieland, S Ishibashi… - Nature …, 2005 - nature.com
Cholesterol in the mammalian brain is a risk factor for certain neurodegenerative diseases,
raising the question of its normal function. In the mature brain, the highest cholesterol content …

Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter

…, T Gotoda, S Kimura, S Ishibashi… - … and cellular biology, 2001 - Am Soc Microbiol
In an attempt to identify transcription factors which activate sterol-regulatory element-binding
protein 1c (SREBP-1c) transcription, we screened an expression cDNA library from adipose …

The two-receptor model of lipoprotein clearance: tests of the hypothesis in" knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both …

S Ishibashi, J Herz, N Maeda… - Proceedings of the …, 1994 - National Acad Sciences
Apolipoprotein E (apoE) is hypothesized to mediate lipoprotein clearance by binding to two
receptors: (i) the low density lipoprotein receptor (LDLR) and (ii) a chylomicron remnant …