A series of 6-(3-amino-2-hydroxypropoxy)-2 (LH)-quinolinones has been synthesized and
evaluated for positive inotropic activity on the canine heart. Some of these derivatives have a …

Two key synthetic analogs of bleomycin A2 (1) are described. The synthesis and evaluation
of demannosylbleomycin A2 (3) lacking the terminal 2-0-(3-0-carbamoyl)-aD-…

We discovered the first nonpeptide arginine‐vasopressin (AVP) V 2 ‐receptor agonist, OPC‐51803.
Pharmacological properties of OPC‐51803 were elucidated using HeLa cells …

NMR studies of the hydroperoxide form of cobalt deglycoBleomycin A2 (HOO−CodGBLM)
and its complex with oligonucleotide d(CCAGGCCTGG) (1, C is the site of cleavage) are …

The synthesis of a full series of analogs 2b-k of deglycobleomycin A 2 (2a) containing
systematic variations in the linker domain of bleomycin A 2 (1) is described. The agents 2b-k, …

Aseries of oxypropanolamine derivatives of 3,4-dihydro-2H-1,4-benzoxazine were synthesized
and evaluated for inotropic, chronotropic and coronary vasodilating activities in the …

The synthesis and comparative examination of 3–5, analogues of deglycobleomycin A 2 (2)
which address the inferred importance of the l-histidine secondary amide directly, are …

A series of 6-(4-amino-1-piperidinyl)carbonyl-2(1H)-quinolinones, and their open form
derivatives, were synthesized and evaluated for their ability to stimulate femoral artery blood flow (…

The synthesis of the full metal binding domain of bleomycin A2 complete with linkage to the
2-0-(3-0-carbamoyl-aD-mannopyranosyl)-aL-gulopyranosyl disaccharide is detailed. Metal …

A series of 1-heteroaroylpiperazines (V-VII, XI) was synthesized and examined for positive
inotropic activities on the canine heart. The key intermediates, heteroarenecarboxylic acids (III…