Human organic anion transporters and human organic cation transporters mediate renal antiviral transport

M Takeda, S Khamdang, S Narikawa, H Kimura… - … of Pharmacology and …, 2002 - ASPET
Renal excretion is an important elimination pathway for antiviral agents, such as acyclovir (ACV),
ganciclovir (GCV), and zidovudine (AZT). The purpose of this study was to elucidate the …

Characterization of methotrexate transport and its drug interactions with human organic anion transporters

M Takeda, S Khamdang, S Narikawa, H Kimura… - … of Pharmacology and …, 2002 - ASPET
Life-threatening drug interactions are known to occur between methotrexate and nonsteroidal
anti-inflammatory drugs (NSAIDs), probenecid, and penicillin G. The purpose of this study …

Interactions of human organic anion transporters with diuretics

…, A Tojo, A Enomoto, N Anzai, S Narikawa… - … of Pharmacology and …, 2004 - ASPET
The tubular secretion of diuretics in the proximal tubule has been shown to be critical for the
action of drugs. To elucidate the molecular mechanisms for the tubular excretion of diuretics, …

Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins

H Kimura, M Takeda, S Narikawa, A Enomoto… - … of Pharmacology and …, 2002 - ASPET
Prostaglandin E 2 (PGE 2 ) and prostaglandin F 2α (PGF 2α ) have been used for the induction
of labor and the termination of pregnancy. Renal excretion is shown to be an important …

Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors

A Enomoto, M Takeda, M Shimoda, S Narikawa… - … of Pharmacology and …, 2002 - ASPET
The organic anion transport system is involved in the tubular excretion and reabsorption of
various drugs and substances. The purpose of this study was to characterize the effects of …

Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs

S Khamdang, M Takeda, R Noshiro, S Narikawa… - … of Pharmacology and …, 2002 - ASPET
The purpose of this study was to elucidate the interactions of human organic anion
transporters (hOATs) and human organic cation transporters (hOCTs) with nonsteroidal anti-…

[HTML][HTML] Role of human organic anion transporter 4 in the transport of ochratoxin A

E Babu, M Takeda, S Narikawa, Y Kobayashi… - … et Biophysica Acta (BBA …, 2002 - Elsevier
The purpose of this study was to investigate the characteristics of ochratoxin A (OTA) transport
by multispecific human organic anion transporter 4 (hOAT4) using mouse proximal tubule …

Interaction of human organic anion transporters with various cephalosporin antibiotics

M Takeda, E Babu, S Narikawa, H Endou - European journal of …, 2002 - Elsevier
Cephalosporin antibiotics are thought to be excreted into the urine via organic anion transporters
(OATs). The purpose of this study was to elucidate the interaction of human-OATs with …

Characterization of ochratoxin A transport by human organic anion transporters

KY Jung, M Takeda, DK Kim, A Tojo, S Narikawa… - Life sciences, 2001 - Elsevier
The purpose of this study was to investigate the characteristics of ochratoxin A (OTA)
transport by multispecific human organic anion transporters (hOAT1 and hOAT3, respectively) …

Expression of human organic anion transporters in the choroid plexus and their interactions with neurotransmitter metabolites

…, H Hasannejad, J Inatomi, S Narikawa… - Journal of …, 2003 - Elsevier
The purpose of the present study was to elucidate the expression of human organic anion
transporter 1 (hOAT1) and hOAT3 in the choroid plexus of the human brain and their …