Variants in the FTO gene have been strongly associated with obesity in a very large sample
(38,759) of diabetic and control subjects. To replicate these findings, the previously reported …

Opioids are first-line drugs for moderate to severe acute pain and cancer pain. However,
these medications are associated with severe side effects, and whether they are efficacious in …

Background Dalazatide is a specific inhibitor of the Kv1.3 potassium channel. The expression
and function of Kv1.3 channels are required for the function of chronically activated …

The Kv1.3 channel is a recognized target for pharmaceutical development to treat autoimmune
diseases and organ rejection. ShK-186, a specific peptide inhibitor of Kv1.3, has shown …

The 2′-5′ oligoadenylate synthetase (OAS) proteins are traditionally considered
intracellular antiviral proteins. However, several studies demonstrate a correlation between the …

The voltage-gated potassium (Kv) 1.3 channel is widely regarded as a therapeutic target for
immunomodulation in autoimmune diseases. ShK-186, a selective inhibitor of Kv1. 3 …

The cellular response to virus infection is initiated when pathogen recognition receptors (PRR)
engage viral pathogen-associated molecular patterns (PAMPs). This process results in …

We report the initial sequencing and comparative analysis of the Macaca mulatta transcriptome.
Cloned sequences from 11 tissues, nine animals, and three species (M. mulatta, M. …

There is a growing need for novel antiviral therapies that are broad spectrum, effective, and
not subject to resistance due to viral mutations. Using high-throughput screening methods, …

Arenaviruses are a significant cause of hemorrhagic fever, an often-fatal disease for which
there is no approved antiviral therapy. Lassa fever in particular generates high morbidity and …